Applications of photosynthetic bacteria for medical fields |
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Authors: | Sasaki Ken Watanabe Masanori Suda Yoshito Ishizuka Akihiro Noparatnaraporn Napavarn |
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Affiliation: | Materials Science and Engineering, Graduate School of Engineering, Hiroshima Kokusai Gakuin University, 6-20-1 Nakano, Akiku, Hiroshima 739-0321, Japan. sasaki@hkg.ac.jp |
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Abstract: | The medical applications of photosynthetic bacteria are summarized. Photosynthetic bacteria can produce various types of physiological active substance such as vitamin B(12), ubiquinone (coenzyme Q10), 5-aminolevulinic acid (ALA), porphyrins and RNA. In particular, photosynthetic bacterial ALA was commercially applied to cancer diagnosis and treatment. Recently, ALA has been applied to the treatment of acne vulgaris and the suppression of the inflammatory response to coronary and iliac injuries. In addition, the recent applications of RNA from a marine photosynthetic bacterium as a medical supplement for immune improvement and suppression of infection are described. Furthermore, the feasible application of a biopolymer consisting of RNA from a photosynthetic bacterium as a drug delivery system (DDS) to cancer treatment is described. |
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Keywords: | photosynthetic bacteria 5-aminolevulinic acid porphyrin RNA drug delivery ALA 5-aminolevulinic acid D dilution rate DCW dry cell weight DDS drug delivery system DO dissolved oxygen EPS extracellular polymeric substance 5FU 5-fluoro-1-urasil HPLC high-pressure liquid chromatography MLSS mixed liquor suspended solid ORP oxidation reduction potential PDT photodynamic therapy PPIX protoporphyrin IX Tegaful 5-fluoro-1-(tetrahydro-2-furfuryl) urasil |
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