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Applications of photosynthetic bacteria for medical fields
Authors:Sasaki Ken  Watanabe Masanori  Suda Yoshito  Ishizuka Akihiro  Noparatnaraporn Napavarn
Affiliation:Materials Science and Engineering, Graduate School of Engineering, Hiroshima Kokusai Gakuin University, 6-20-1 Nakano, Akiku, Hiroshima 739-0321, Japan. sasaki@hkg.ac.jp
Abstract:The medical applications of photosynthetic bacteria are summarized. Photosynthetic bacteria can produce various types of physiological active substance such as vitamin B(12), ubiquinone (coenzyme Q10), 5-aminolevulinic acid (ALA), porphyrins and RNA. In particular, photosynthetic bacterial ALA was commercially applied to cancer diagnosis and treatment. Recently, ALA has been applied to the treatment of acne vulgaris and the suppression of the inflammatory response to coronary and iliac injuries. In addition, the recent applications of RNA from a marine photosynthetic bacterium as a medical supplement for immune improvement and suppression of infection are described. Furthermore, the feasible application of a biopolymer consisting of RNA from a photosynthetic bacterium as a drug delivery system (DDS) to cancer treatment is described.
Keywords:photosynthetic bacteria  5-aminolevulinic acid  porphyrin  RNA  drug delivery  ALA  5-aminolevulinic acid  D  dilution rate  DCW  dry cell weight  DDS  drug delivery system  DO  dissolved oxygen  EPS  extracellular polymeric substance  5FU  5-fluoro-1-urasil  HPLC  high-pressure liquid chromatography  MLSS  mixed liquor suspended solid  ORP  oxidation reduction potential  PDT  photodynamic therapy  PPIX  protoporphyrin IX  Tegaful  5-fluoro-1-(tetrahydro-2-furfuryl) urasil
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