Hypolipidemic and antioxidative effects of rice bran and phytic acid in high fat-fed mice |
| |
Authors: | Mi Young Kang Soo Mi Kim Catherine W Rico Sang-Chul Lee |
| |
Affiliation: | 2. Department of Food Science and Nutrition, Kyungpook National University, Daegu, 702-701, Korea 1. Division of Plant Biosciences, Kyungpook National University, Daegu, 702-701, Korea
|
| |
Abstract: | The influence of rice bran and phytic acid on lipid metabolism and antioxidative status in high fat-fed mice was investigated.
The mice were given high fat diet (HF) or high fat diet supplemented with rice bran (HF-RB) or phytic acid (HF-PA) for 7 weeks.
The control mice (NC) received normal diet. The HF mice showed marked increase in body weight, total cholesterol levels, hepatic
triglyceride concentration, and lipid peroxidation rate compared with NC group. Also, a significant decrease in antioxidant
enzyme activities was observed in HF animals. Addition of rice bran and phytic acid in the diet counteracted this high fatinduced
hyperlipidemia and oxidative stress, mainly by increasing fecal lipid excretion and regulation of antioxidant and lipogenic
enzyme activities. These findings illustrate that rice bran and phytic acid possess antihyperlipidemic action and antioxidant
status-improving ability, and may be beneficial as dietary supplements in the management of high fat diet-induced hyperlipidemia. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|