竹红菌素-聚(甲基丙烯酸甲酯-co-甲基丙烯酸)纳米纤维的制备及其光敏抗菌性能

针对抗生素类药物在耐药性菌株处理中应用的局限性,在聚(甲基丙烯酸甲酯-co-甲基丙烯酸)纺丝液中添加光敏剂竹红菌素,采用静电纺丝法制备具有光动力广谱抗菌功能的纳米纤维膜。借助扫描电子显微镜、静态接触角测试、傅里叶变换红外光谱仪和热重分析仪等分析添加竹红菌素前后纳米纤维的形貌、润湿性能、化学结构和热稳定性,并研究了添加竹红菌素的纳米纤维膜对金黄色葡萄球菌和大肠杆菌的抗菌能力。结果表明:添加竹红菌素后纳米纤维直径变粗,静态接触角增加约20°,润湿性能下降,热稳定性略有降低;纤维膜在可见光下具有良好的光动力氧化性能,在光照下对金黄色葡萄球菌和大肠杆菌的抑菌率分别达99.97%和54.41%。

Preparation and photodynamic antimicrobial properties of hypocrellinpoly(methyl methacrylate-co-methacrylic acid) nanofibers

To overcome the limitation of antibiotic drugs in the treatment of drug resistant strains, photosensitizer hypocrellin(Hc)was added to the poly(methyl methacrylate-co-methacrylic acid) electrospinning solution to prepare the photodynamic broad-spectrum antibacterial nanofibrous membrane. The overall morphology, wettability, chemical structure and thermostability of the nanofibers before and after the addition of Hc were compared by scanning electron microscopy, static contact angle test, Fourier transform infrared spectrometry and thermogravimetric analysis, and the antibacterial ability to S. aureus and E. coli were also investigated. The results show that the addition of Hc causes increase in the diameter of nanofibers, increases its static contact angle by approximately 20° and decreases its wettability, slightly decreases its thermostability, and imparts good substrate oxidation under visible light. The antibacterial effect against S. aureus and E. coli reached 99.97% and 54.41% under light conditions, respectively.