| 化学改性对山药多糖抗肿瘤活性的影响 |
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| 引用本文： | 赵国华,李志孝,陈宗道.化学改性对山药多糖抗肿瘤活性的影响[J].中国食品学报,2004,4(1):39-42. |
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| 作者姓名： | 赵国华 李志孝 陈宗道 |
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| 作者单位： | 1. 西南农业大学食品科学学院,重庆,400716
2. 兰州大学应用有机化学国家重点实验室,兰州,730070 |
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| 基金项目： | 国家自然科学基金(No.39730480) |
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| 摘 要： | 利用多糖化学改性方法和动物移植性实体瘤实验,研究了5种化学改性方法(羧甲基化、乙酰化、甲基化、硫酸化以及部分降解)对山药多糖RDPS-1抗肿瘤活性的影响,结果发现化学改性对多糖的生物活性有显著的影响。低度羧甲基化、低度甲基化和中度乙酰化能显著地提高多糖的抗肿瘤活性,而部分降解和硫酸化使多糖的抗肿瘤活性显著降低。
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| 关 键 词： | 山药 多糖 抗肿瘤 化学改性 |
| 文章编号： | 1009-7848(2004)01-0039-04 |
| 修稿时间： | 2002年10月23 |
Effects of Chemical Modification on Antitumor Activity of Polysaccharides Isolated from Chinese Yam |
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| Zhao Guohua,Li Zhixiao,Chen Zongdao.Effects of Chemical Modification on Antitumor Activity of Polysaccharides Isolated from Chinese Yam[J].Journal of Chinese Institute of Food Science and Technology,2004,4(1):39-42. |
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| Authors: | Zhao Guohua Li Zhixiao Chen Zongdao |
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| Abstract: | Effects of carboxymethylation, acetylation, methylation, sulfation and partial degradation on the antitumor activity of RDPS-I were studied with chemical modification melhods and animal experiments. The results indicated that chemical modification had a significant influence on the antitumor activity of RDPS-I. Lower degree of carboxymethylation and methylation, medium degree of acetylation could greatly improve the antitumor activity of RDPS-I, but the sulfation and partial degradation lowered the antitumor activity seriously. |
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| Keywords: | Chinese yam Polysaccharide Antitumor Chemical modification |
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