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| 米糠肽对D-半乳糖致衰小鼠线粒体损伤的影响 | |
| 引用本文： | 樊金娟,付岩松,宗立立,张心昱,罗霞.米糠肽对D-半乳糖致衰小鼠线粒体损伤的影响[J].中国粮油学报,2011,26(1):30-34. |
| 作者姓名： | 樊金娟 付岩松 宗立立 张心昱 罗霞 |
| 作者单位： | 1. 沈阳农业大学生物科学技术学院,沈阳,110866 2. 吉林农业大学农学院,长春,130118 3. 中国科学院地理科学与资源研究所,北京,100101 |
| 基金项目： | 辽宁省教育厅重点实验室项目 |
| 摘 要： | 利用D-半乳糖(D-gal)致衰小鼠模型,探讨了米糠肽对小鼠心、脑线粒体锰超氧化物歧化酶(Mn-SOD)活性、丙二醛(MDA)含量以及总抗氧化能力(T-AOC)和Ca2+泵、Na+泵活性的影响,并以透射电镜观察了该肽对小鼠肝细胞及线粒体超微结构的影响。结果显示,与衰老组相比,高剂量米糠肽(500 mg/kg)可明显降低小鼠心、脑线粒体MDA含量(P<0.01),显著提高T-AOC(P<0.01)、Mn-SOD活性(P<0.01)以及Ca2+泵、Na+泵活性,优于中、低剂量(200、100 mg/kg);透射电镜下可见衰老组肝线粒体肿胀明显,膜模糊不清,有空泡形成,而米糠肽各组线粒体损伤程度有所减轻。说明米糠肽对D-gal致衰小鼠线粒体损伤起到良好的保护作用,可能具有延缓衰老的效果。 |
| 关 键 词： | 米糠肽 衰老模型 线粒体 超微结构 |
Effect of Rice Bran Peptides on Mitochondria Injury in Aging Mice Induced by D-Galactose |
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| Fan Jinjuan,Fu Yansong,Zong Lili,Zhang Xinyu,Luo Xia.Effect of Rice Bran Peptides on Mitochondria Injury in Aging Mice Induced by D-Galactose[J].Journal of the Chinese Cereals and Oils Association,2011,26(1):30-34. | |
| Authors: | Fan Jinjuan Fu Yansong Zong Lili Zhang Xinyu Luo Xia |
| Affiliation: | Fan Jinjuan1 Fu Yansong1 Zong Lili2 Zhang Xinyu3 Luo Xia1(College of biotechnology,Shenyang Agricultural University1,Shenyang 110866)(College of agricultural,Jilin Agricultural University2,Changchun 130118) (Institute of Geographical Sciences and Natural Resources Research3,CAS,Beijing 100101) |
| Abstract: | The aging mice models induced by D-galactose(D-gal) were created to reveal the effect of rice bran peptides on the activity of manganese-superoxide dimutase(Mn-SOD),content of malonadehide(MDA),total antioxidation capacity(T-AOC),and activities of Ca2+-Mg2+-ATPase and Na+-K+-ATPase in mice heart and brain mitochondria,as well as on the ultrastructure of liver cell and mitochondria under transmission electron microscopy(TEM).Results:Compared with aging group,the rice bran peptides of 500 mg/kg dose greatly d... |
| Keywords: | rice bran peptide aging model mitochondria ultrastructure |
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