| 海藻酸钠对氯霉素在滴眼液中缓释作用研究 |
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| 引用本文： | 李鹏,贾瑞,贺艳丽.海藻酸钠对氯霉素在滴眼液中缓释作用研究[J].食品与药品,2012(3):102-104. |
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| 作者姓名： | 李鹏 贾瑞 贺艳丽 |
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| 作者单位： | 山东大学药学院;山东省生物药物研究院 |
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| 摘 要： | 目的研究海藻酸钠对氯霉素在滴眼液中释放的影响。方法配制影响因素不同的氯霉素溶液,采用side-bi-side扩散池,测定药物渗透速率。结果氯霉素释放速率随溶液黏度增加而降低,随氯霉素浓度增加而提高。结论氯霉素在滴眼液中的释放速率与溶液黏度和药物浓度有关,适当增加海藻酸钠含量可延缓其释放速率。
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| 关 键 词： | 海藻酸钠 氯霉素 药物释放 |
Influence of Sodium Alginate on Chloramphenicol Release in Eye Drops |
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| LI Peng,JIA Rui,HE Yan-li.Influence of Sodium Alginate on Chloramphenicol Release in Eye Drops[J].Food and Drug,2012(3):102-104. |
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| Authors: | LI Peng JIA Rui HE Yan-li |
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| Affiliation: | 1,2) (1.School of Pharmaceutical Sciences,Shandong University,Jinan 250012,China;2.Institute of Biopharmaceuticals of Shandong Province,Jinan 250101,China) |
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| Abstract: | Objective To study the influence of sodium alginate on chloramphenicol release in eye drops.Methods The penetration rates of chloramphenicol were determined with side-bi-side diffusion cell in solutions with different influence factors.Results The release rate of chloramphenicol was decreased with the viscosity increase of solutions, and increased with the increase of chloramphenicol’s concentration.Conclusion The release rate of chloramphenicol in eye drops is in association with the viscosity of solutions as well as its concentration,which can be decreased by increasing the concentration of sodium alginate to some extent. |
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| Keywords: | sodium alginate chloramphenicol drug release |
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