塑料包装食品及饮品检测中双酚类标准物质的应用

双酚类物质（BPs）类别多且结构相似，有特殊毒性，属内分泌干扰物，对人类健康有潜在危害，近年相关研究逐渐增多并涉及标准物质。本文依托近11年(2011-2021)国内外对塑料包装食品及饮品中BPs的研究情况，发现BPs存在基质较多，检出种类丰富；近年来BPs标准物质使用比例逐年上升，近三年接近80%，说明BPs相关研究出现热潮；研究主要由高校/科研院所开展，未经广泛监测和应用研究，结合BPs毒理学数据缺乏和相关立法空白现状，说明其研究在起步阶段，标准物质应用和拓展空间较大。本文对BPs的总结与建议，揭示了BPs危险性，促使人们关注其研究进展，增加标准物质使用比例，制定标准检测方法；助力我国对BPs标准物质的建设；有利于加强食品生产质量监控；鼓励低毒型BPs替代品的探索；改良包装材料制备工艺等。

Research progress of the application of reference materials in the detection of bisphenols in plastic packaged food and beverages

There are many types of bisphenols (BPs) with similar structures and special toxicity. They are endocrine disruptors and have potential harm to human health. In recent years, related research that involved standard substances had gradually increased. Based on the recent 11 years (2011-2021) of domestic and foreign research on BPs in plastic packaged food and beverages, it was found that BPs existed in many matrices, and the types of them were abundant. It was also found that the proportion that the BPs reference materials were used had increased year by year in recent years, reaching nearly 80% in the past 3 years, indicating a boom in BPs-related research. What''s more, the research was mainly carried out by universities/research institutes without extensive monitoring and application research. Combined with the current status that the toxicological data of BPs is lacking and the relevant legislation is in the blank, it could be inferred that the research is in its infancy, and there would be a large space for the application and expansion of reference materials. The summary and suggestions of BPs in this paper revealed the danger of BPs, prompting people to pay attention to their research progress and increase the proportion of reference materials to formulate standard detection methods. This paper will also help China to build BPs reference materials and strengthen food production quality monitoring. It might conduce the exploration of alternatives to toxic BPs and the improvement of the preparation process of packaging materials, etc.