| 高效液相色谱-串联质谱法测定能力验证肉粉中四环素类抗生素残留量 |
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| 引用本文： | 盘正华,辛丽娜,黄燕红,谭喜梅,韦 钰,蒋定之.高效液相色谱-串联质谱法测定能力验证肉粉中四环素类抗生素残留量[J].食品安全质量检测技术,2019,10(10):3120-3125. |
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| 作者姓名： | 盘正华 辛丽娜 黄燕红 谭喜梅 韦 钰 蒋定之 |
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| 作者单位： | 广西-东盟食品药品安全检验检测中心 |
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| 摘 要： | 目的优化肉粉样品中四环素类药物的高效液相色谱-串联质谱检测方法。方法采用80%乙腈-水溶液提取肉粉样品中的四环素类药物,Prime HLB固相萃取小柱净化,洗脱液用氮气吹至近干,用10%乙腈水溶液(含0.2%甲酸)溶解,采用多反应监测正离子模式(multiple reaction monitoring, MRM)进行高效液相色谱-串联质谱仪测定。结果与国标方法GB/T 21317-2007(HLB固相小柱萃取法)相比,4种药物的线性范围均在5～200μg/L时线性良好(r 0.99),回收率差异不显著(P0.05)。实验室方法测得的含量分别为:四环素113.93μg/kg,金霉素68.16μg/kg,多西环素155.73μg/kg,土霉素未检出;回收率为四环素94.5%,金霉素95.2%,多西环素104.7%,土霉素97.8%。测得四环素、金霉素、多西环素、土霉素线性相关系数r分别为:0.9995、0.9998、0.9989、0.9997。结论本实验室方法简单快速,回收率高,重现性好,适用于熟肉制品中四环素类药物的多残留检测。
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| 关 键 词： | 四环素类抗生素 高效液相色谱-串联质谱法 残留量 |
| 收稿时间： | 2019/4/16 0:00:00 |
| 修稿时间： | 2019/4/23 0:00:00 |
Determination of 4 kinds of tetracycline antibiotics in meat powder samples from food analysis performance assessment scheme by high performance liquid chromatography-tandem mass spectrometry |
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| PAN Zheng-Hu,XIN Li-N,HUANG Yan-Hong,TAN Xi-Mei,WEI Yu and JIANG Ding-Zhi.Determination of 4 kinds of tetracycline antibiotics in meat powder samples from food analysis performance assessment scheme by high performance liquid chromatography-tandem mass spectrometry[J].Food Safety and Quality Detection Technology,2019,10(10):3120-3125. |
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| Authors: | PAN Zheng-Hu XIN Li-N HUANG Yan-Hong TAN Xi-Mei WEI Yu and JIANG Ding-Zhi |
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| Affiliation: | Guangxi and Asean Inspection Testing Center for Food and Drug Safety,Guangxi and Asean Inspection Testing Center for Food and Drug Safety,Guangxi and Asean Inspection Testing Center for Food and Drug Safety,Guangxi and Asean Inspection Testing Center for Food and Drug Safety,Guangxi and Asean Inspection Testing Center for Food and Drug Safety and Guangxi and Asean Inspection Testing Center for Food and Drug Safety |
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| Abstract: | |
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| Keywords: | tetracycline antibiotics high performance liquid chromatography-tandem mass spectrometry residues |
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