| 超高效液相色谱-串联质谱法测定酒、牡蛎粉、 咖啡中2种那非类物质的含量 |
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| 引用本文： | 金绍明,高文超,宁 霄,曹 进,丁 宏. 超高效液相色谱-串联质谱法测定酒、牡蛎粉、 咖啡中2种那非类物质的含量[J]. 食品安全质量检测学报, 2017, 8(7): 2448-2452 |
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| 作者姓名： | 金绍明 高文超 宁 霄 曹 进 丁 宏 |
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| 作者单位： | 中国食品药品检定研究院食品检定所,中国食品药品检定研究院食品检定所,中国食品药品检定研究院食品检定所,中国食品药品检定研究院食品检定所,中国食品药品检定研究院食品检定所 |
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| 摘 要： | 目的建立超高效液相色谱-串联质谱法(ultra performance liquid chromatography-tandem mass spectrometry,UPLC-MS/MS)测定酒、牡蛎粉、咖啡中那非类物质含量的分析方法。方法采用Waters HSS T3(2.1 mm×100 mm,1.8μm)反相色谱柱,以0.1%甲酸水和0.1%甲酸乙腈为流动相进行梯度洗脱,经质谱多反应监测(multiple reaction monitor,MRM)法进行检测。结果在10~200 ng/mL的浓度范围内,去甲基他达拉非和硫代西地那非均表现出良好的线性关系,2种化合物的检出限分别为50 ng/g和50 ng/mL,定量限分别为100 ng/g和100 ng/mL。结论该方法操作简便,结果可靠,灵敏度高,可用于食品中去甲基他达拉非和硫代西地那非含量的快速测定。
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| 关 键 词： | 超高效液相色谱—串联质谱 去甲基他达拉非 硫代西地那非 食品 |
| 收稿时间： | 2017-05-08 |
| 修稿时间： | 2017-06-25 |
Determination of nortadalafil and thiosildenafil in wine, oyster powder and coffee by ultra performance liquid chromatography-tandem mass spectrometry |
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| JIN Shao-Ming,GAO Wen-Chao,NING Xiao,CAO Jin and DING Hong. Determination of nortadalafil and thiosildenafil in wine, oyster powder and coffee by ultra performance liquid chromatography-tandem mass spectrometry[J]. Journal of Food Safety & Quality, 2017, 8(7): 2448-2452 |
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| Authors: | JIN Shao-Ming GAO Wen-Chao NING Xiao CAO Jin DING Hong |
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| Affiliation: | Institute for Food Control,National Institutes for Food and Drug Control,Institute for Food Control,National Institutes for Food and Drug Control,Institute for Food Control,National Institutes for Food and Drug Control,Institute for Food Control,National Institutes for Food and Drug Control,Institute for Food Control,National Institutes for Food and Drug Control |
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| Abstract: | |
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| Keywords: | UPLC-MS/MS Nortadalafil Thiosildenafil foods |
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