| 基于迪恩涡流的流式三维聚焦芯片设计和仿真 |
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| 引用本文： | 吴云良,王策,严心涛,马玉婷,武晓东. 基于迪恩涡流的流式三维聚焦芯片设计和仿真[J]. 分析仪器, 2017, 0(4). DOI: 10.3969/j.issn.1001-232x.2017.04.022 |
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| 作者姓名： | 吴云良 王策 严心涛 马玉婷 武晓东 |
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| 作者单位： | 中国科学院苏州生物医学工程技术研究所,苏州,215163 |
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| 基金项目： | 中科院重点部署项目"新型超微量免疫检测仪及配套试剂"，科技部重点专项"常见单基因病及基因组病无创产前筛查及诊断技术平台研发及规范化应用体系建立" |
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| 摘 要： | 根据迪恩涡流理论,设计了一个利用平面微加工工艺可以制作的流式三维聚焦芯片,并用FLUENT进行了仿真分析。研究了在弯管结构中,迪恩涡流的变化过程,以及样品被聚焦的过程。分析了不同的样品流速、鞘液流速对聚焦效果的影响。仿真结果验证了流式三维聚焦芯片的功能,并为三维聚焦系统控制提供了依据。
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| 关 键 词： | 流式细胞术 迪恩涡流 三维聚焦 |
Design and simulation of three-dimensional focusing microfluidic chip based on Dean vortex |
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| Wu Yunliang,Wang Ce,Yan Xintao,Ma Yuting,Wu Xiaodong. Design and simulation of three-dimensional focusing microfluidic chip based on Dean vortex[J]. Analytical Instrumentation, 2017, 0(4). DOI: 10.3969/j.issn.1001-232x.2017.04.022 |
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| Authors: | Wu Yunliang Wang Ce Yan Xintao Ma Yuting Wu Xiaodong |
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| Abstract: | A three-dimensional focusing microfluidic chip which can be fabricated with plane micro machining technology, was designed based on Dean vortices theory, and simulated by FLUENT.The changing process of the Dean vortex and the focusing process of the sample in the curved pipe were studied.The influence of sample flow rate, sheath flow rate on the focusing capability were discussed.The simulated result verified the function of the chip and provided a reference to the control of the three-dimensional focusing microfluidic chip. |
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| Keywords: | flow cytometry Dean vortex three-dimensional focusing |
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