| LC-MS/MS法定量测定人血浆中CPRC-127血药浓度 |
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| 引用本文： | 王博雅,赵芊,江骥,胡蓓.LC-MS/MS法定量测定人血浆中CPRC-127血药浓度[J].质谱学报,2009,30(Z1):107-108. |
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| 作者姓名： | 王博雅 赵芊 江骥 胡蓓 |
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| 作者单位： | 中国医学科学院&中国协和医科大学，北京协和医院，临床药理研究中心，北京 100730 |
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| 摘 要： |
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Quantitation of CPRC-127 in Human Plasma by LC-MS/MS |
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| WANGBo-ya,ZHAOQian,JIANGJi,HUPei.Quantitation of CPRC-127 in Human Plasma by LC-MS/MS[J].Journal of Chinese Mass Spectrometry Society,2009,30(Z1):107-108. |
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| Authors: | WANGBo-ya ZHAOQian JIANGJi HUPei |
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| Affiliation: | Clinical Pharmacology Research Center, Peking Union Medical College Hospital,
Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
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| Abstract: | A sensitive liquid chromatography-electrospray ionization-tandem mass spectrometric(LC-MS/MS) method for the determination of CPRC-127 in human plasma was developed and validated. The plasma was extracted using a liquid-liquid phase extraction(LLE), and the sample extract was injected onto the LC-MS/MS system. The limit of quantitation(LLOQ) for CPRC-127 is 0.5 μg•L－1. This method allows the reproducible and accurate quantification with the concentration range of 0.5-1 000 μg•L－1. This method can be applied to the quantitation of CPRC-127 in human plasma. |
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| Keywords: | CPRC-127 LC-MS/MS quantitation |
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