| 质谱电喷雾电离源研究新进展 |
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| 引用本文： | 李佳斌,郝斐然,田芳,张养军.质谱电喷雾电离源研究新进展[J].质谱学报,2013,34(2):65-74. |
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| 作者姓名： | 李佳斌 郝斐然 田芳 张养军 |
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| 作者单位： | 蛋白质组学国家重点实验室，北京蛋白质组研究中心，军事医学科学院放射与辐射医学研究所，北京102206 |
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| 基金项目： | 国家自然科学基金项目，国家重大科学计划项目，国家重大科学仪器设备开发专项 |
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| 摘 要： | 自1984年约翰芬恩(John Fenn)发明一种软电离离子源,即电喷雾电离源(ESI)以来,促进了质谱技术在大分子分析领域,特别是生物大分子领域的广泛使用。ESI源的低取样效率由ESI源的离子化效率和传输效率的构成,制约着ESI源质谱灵敏度的提高,因此研究者们一直努力改进ESI源的性能,以提高取样效率、改善ESI源质谱灵敏度。本研究介绍了ESI源的原理,并评述了近年来ESI源研究的新进展和应用。
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| 关 键 词： | 电喷雾离子源 离子化效率 取样效率 |
Advances of Electrospray Ionization Source for Mass Spectrometry |
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| LI Jia-bin
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HAO Fei-ran
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TIAN Fang
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ZHANG Yang-jun.Advances of Electrospray Ionization Source for Mass Spectrometry[J].Journal of Chinese Mass Spectrometry Society,2013,34(2):65-74. |
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| Authors: | LI Jia-bin HAO Fei-ran TIAN Fang ZHANG Yang-jun |
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| Affiliation: | State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 102206， China |
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| Abstract: | The electrospray ionization(ESI) source has been widely used for the identication and quantification of macromolecules especially biomacromolecules since John Fenn developed the soft ion source in 1984. ESI suffers from low sampling efficiency consisting of ionization efficiency and transmission efficiency, which directly limits the detection sensitivity of a mass spectrometer. So scientists working in this field have paid great attention to improve sampling efficiency. In this review, the theory of ESI source is introduced in detail, and the recent improvement of electrospray ionization source is reviewed. |
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| Keywords: | electrospray ionization source ionization efficiency sampling efficiency |
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