|
|||||
|
|
| 谱域光学相干层析成像量化技术及其在生物组织定量分析中的应用 | |
| 引用本文： | 张芹芹,吴晓静,朱思伟,高志,袁小聪.谱域光学相干层析成像量化技术及其在生物组织定量分析中的应用[J].光学精密工程,2012,20(6):1188-1193. |
| 作者姓名： | 张芹芹 吴晓静 朱思伟 高志 袁小聪 |
| 作者单位： | 1. 南开大学现代光学研究所光学信息技术科学教育部重点实验室,天津,300071 2. 南开大学人民医院分子医学与纳米光学实验室,天津,300121 3. 克莱姆森大学生物工程系,南罗来纳州克莱姆森29634 |
| 基金项目： | 国家自然科学基金资助项目，天津市科学技术委员会基金资助项目 |
| 摘 要： | 研究了谱域光学相干层析(SDOCT)成像系统的量化技术,通过量化OCT图像来获得生物组织内部的信息特征对组织光学散射特性进行定量分析.给出并讨论了单次散射模型,具有轴向点散射函数(PSF)的单次散射模型和多次散射模型,利用平均A-scan算法和非线性最小二乘法曲线拟合,研究不同浓度IntralipidTM溶液的散射特性.实验显示,IntralipidTM溶液的散射系数与浓度在1％～10％间基本呈线性关系,验证了具有PSF的单次散射模型比较适用于本文的谱域光学相干层析成像系统.利用该模型对小鼠的新鲜肝脏进行量化研究,得到小鼠新鲜肝脏在波长λ.为1550 nm时的散射系数为8.9 mm-1.本文的研究为该项技术今后在临床医学上对各种疾病的诊断和治疗奠定了基础. |
| 关 键 词： | 光学相干层析成像 生物组织 谱域 散射模型 量化 |
| 收稿时间： | 2011/12/27 |
Quantitative spectral domain optical coherence tomography and its application to quantitative analysis of biological tissues |
|
| ZHANG Qin-qin , WU Xiao-jing , ZHU Si-wei , GAO Zhi , YUAN Xiao-cong.Quantitative spectral domain optical coherence tomography and its application to quantitative analysis of biological tissues[J].Optics and Precision Engineering,2012,20(6):1188-1193. | |
| Authors: | ZHANG Qin-qin WU Xiao-jing ZHU Si-wei GAO Zhi YUAN Xiao-cong |
| Affiliation: | 1(1.Key Laboratory of Optical Information Science & Technology of the Ministry of Education,Institute of Modern Optics,Nankai University,Tianjin 300071,China; 2.Laboratory of Molecular Medicine and Nano Optics,Nankai University Affiliated Hospital,Tianjin 300121,China; 3.Department of Bioengineering,Clemson University,Clemson 29634,USA) |
| Abstract: | The quantitative analysis of spectral domain optical coherence tomography was researched to acquiring interior information of biological tissues.The single-scattering model,confocal single-scattering model and multiple-scattering model were presented and discussed.An average A-scan algorithm and a nonlinear curve-fitting method were employed to explore the scattering features of IntralipidTM.Experiments show that the relation of scattering coefficients and concentrations is linear in concentrations from 1% to 10% of IntralipidTM.Fourthermore,it confirm that the confocal single-scattering model is suitable to our spectral domain optical coherence tomography.In addition,the confocal model was used to study fresh rat liver with a scattering coefficient λ0 of 8.9 mm-1 at 1 550 nm.Obtained results demonstrate that the quantitative spectral domain optical coherence tomography can be used for clinical diagnosis of diseases in a great potential. |
| Keywords: | optical coherence tomography biological tissue spectral domain scattering model quantitative analysis |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |