Functions of ULK1 in autophagy and non-autophagy pathways and its implications in human physiology and disease |
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Authors: | LINNA TAN YUYONG TAN DELIANG LIU |
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Affiliation: | 1.Department of Gastroenterology, the Second Xiangya Hospital, Changsha, 410011, China
2 Research Center of Digestive Disease, Central South University, Changsha, 410011, China |
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Abstract: | ULK1 (unc-51 like autophagy activating kinase 1), a mammalian serine/threonine kinase, is a key component of
autophagy initiation complex and helps to induce all types of autophagy. Canonical autophagy is a process in which,
through the interactions of a series of autophagy-related proteins, damaged organelles or misfolded proteins are
engulfed by autophagosomes and then merged with lysosomes to be degraded. Thus, canonical autophagy is an
important constituent part of the cellular “quality control.” Besides, accumulating evidence indicates that ULK1 exerts
autophagy-independent effects in a cell-specific manner. For example, ULK1 facilitates neurite elongation through the
regulation of endoplasmic reticulum (ER)–Golgi trafficking in neurons, stimulates phosphopentose pathway to help
NADPH (nicotinamide adenine dinucleotide phosphate hydrogen) production, and acts as a duplex regulator in type
I IFN (type I interferon) induced innate immune response. Considering the importance and diversity of ULK1 in
various biological processes, this review aims to present a comprehensive overview of autophagy and non-autophagy
related functions of ULK1 in a variety of human physiological, pathological, and disease processes. |
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Keywords: | Ubiquitination Axonal extension Cancer Metabolism Immune response Stress |
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