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| HPLC法检查阿昔洛韦分散片的有关物质 | |
| 引用本文： | 王倩,刘新元,王桂燕.HPLC法检查阿昔洛韦分散片的有关物质[J].现代仪器,2006,12(4):28-30. |
| 作者姓名： | 王倩 刘新元 王桂燕 |
| 作者单位： | 1. 天津市医药科学研究所,天津,300070 2. 天津隆顺榕制药厂,天津,300011 3. 天津市蓝恒医药化工技术研究所,天津,300074 |
| 摘 要： | 目的:采用高效液相色谱法检查阿昔洛韦分散片的有关物质。方法:色谱柱为C18,200×4.6mm,5μm,以甲醇∶水(8∶92)为流动相,检测波长为254nm。结果:阿昔洛韦浓度在0.5~7.5μg/mL范围内(r=0.9996,n=5),鸟嘌呤浓度在0.5~8.5μg/mL范围内(r=0.9996,n=5),线性均良好。有关物质测定重复性试验鸟嘌呤RSD为1.0%(n=6);其他杂质RSD为1.3%(n=6)。结论方法简便、可靠,可用于生产的质量控制。 |
| 关 键 词： | 阿昔洛韦分散片 高效液相色谱 有关物质 |
HPLC for the determination of relative substances in Acyclovir dispersed tablets |
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| Wang Qian,Liu Xinyuan,Wang Guiyan.HPLC for the determination of relative substances in Acyclovir dispersed tablets[J].Modern Instruments,2006,12(4):28-30. | |
| Authors: | Wang Qian Liu Xinyuan Wang Guiyan |
| Abstract: | Objective To establish HPLC method to determine the relative substances in Acyclovir dispersed tablets.Method In the method C18(200×4.6mm,5μm) as the column and methanol-water(8:92) as the mobile phase and the detection wavelenth of 254nm was specified.Result The linear range of Acyclovir was 0.5～7.5μg/mL(r=0.9996,n=5) and Guanine was 0.5～8.5μg/mL(r=0.9996,n=5).Relative substances repeated experiments: RSD of Guanine was 1.0%(n=6),and RSD of other relative substances was 1.3%(n=6).Conclusion The method is convenient,reliable.It can be used to quality control. |
| Keywords: | Acyclovir dispersed tablets HPLG Relative substances |
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