用钼酸盐高灵敏共振瑞利散射法测定米托蒽醌

在盐酸和硝酸介质中用共振瑞利散射法测定了血清和尿液中的米托蒽醌, 结果表明, 该方法的灵敏度高, 对米托蒽醌的检出限为6 ng/mL(硝酸介质)和8 ng/mL(盐酸介质), 可用于血清和尿样中米托蒽醌的测定.

Determination of Mitoxantrone via Ammonium Molybdate Using High Sensitive Resonance Rayleigh Scattering Method

In 0.12 mol/L hydrochloric acid and nitric acid media,mitoxantrone interacted with molybdate to form an ion-association complex,which can result in the significant enhancement of RRS intensity.The(maximum) scattering wavelengths were 365 nm for RRS and scattering intensities are proportional to the concentration of mitoxantrone,which can be applied to the determination of mitoxantrone.The detection limits are(6 ng/mL) in nitric acid and 8 ng/mL in hydrochloric acid respectively.Because there are not such interactions between anthracycline anticancer drugs such as daunorubicin and epirubicin with molybdate,mitoxantrone can be determined selectively with other anthracycline anticancer drugs existing.The optimum experiment condition,affecting factor and the effect of coexisting substance were investigated in the paper.The application to the determination of mitoxantrone in serum and urine by RRS were not only sensitive but also simple and ra-pid.In addition,the interaction mechanism was discussed.