| 西归粗多糖对运动疲劳小鼠的免疫调节作用 |
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| 引用本文： | 刘兴琴, 丁济超, 李继兴, 孟东, 沈磊, 郭美仙, 刘晓波. 西归粗多糖对运动疲劳小鼠的免疫调节作用[J]. 食品工业科技, 2021, 42(5): 317-321,327. DOI: 10.13386/j.issn1002-0306.2020040200 |
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| 作者姓名： | 刘兴琴 丁济超 李继兴 孟东 沈磊 郭美仙 刘晓波 |
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| 作者单位： | 1.大理大学药学与化学学院, 云南大理 671000 |
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| 基金项目： | 云南省地方本科高校(部分)基础研究面上项目(2017FH001-095);大理大学2017年大学生科研立项项目(KYSX2018170)。 |
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| 摘 要： | 目的:探讨西归粗多糖对运动疲劳小鼠的免疫调节作用.方法:随机将小鼠分为正常对照组、模型对照组,西归粗多糖低、中、高(100、200、400 mg/kg)剂量组5 组,灌胃给药后迫使小鼠游泳直至疲劳,持续10 d,检测其对小鼠碳粒廓清指数、脏器指标,血清BUN、IL-4、IFN-γ、白蛋白、IgG、ALT含量的影响,评价...
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| 关 键 词： | 西归 粗多糖 免疫平衡 运动疲劳 |
| 收稿时间： | 2020-04-17 |
Immunomodulation of Polysaccharides from Xigui in Exercise-induced Fatigue Mice |
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| LIU Xingqin, DING Jichao, LI Jixing, MENG Dong, SHEN Lei, GUO Meixian, LIU Xiaobo. Immunomodulation of Polysaccharides from Xigui in Exercise-induced Fatigue Mice[J]. Science and Technology of Food Industry, 2021, 42(5): 317-321,327. DOI: 10.13386/j.issn1002-0306.2020040200 |
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| Authors: | LIU Xingqin DING Jichao LI Jixing MENG Dong SHEN Lei GUO Meixian LIU Xiaobo |
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| Affiliation: | 1.College of Pharmacy and Chemistry, Dali University, Dali 671000, China |
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| Abstract: | Objective:To investigate the immunomodulation of the crude polysaccharides from xigui on exercise-induced fatigue mice.Methods:Mice were randomly divided into 5 groups:Normal control group,model control group high-,medium-,and low-dose of crude polysaccharide from xigui group(100,200,400 mg/kg).Each mice was administered with corresponding drugs everyday by gavage,and then was forced to swim until fatigue for successive 10 days.The effects of polysaccharide from xigui on the carbon particle clearance index and the organ index of each mouse,the concentrations of BUN,IL-4,IFN-γ,ALB,IgG and ALT in mice’s serum were detected to evaluate its immunomodulatory effect on exercise-induced fatigue mice.Results:The low,middle and high dose group of crude polysaccharide from xigui had certain immunomodulatory effects on the exercise-induced fatigue mice,and the middle dose group(200 mg/kg)had the best effect.The carbon particle clearance index and phagocytosis coefficient were significantly upregulated in the low dose group(P<0.05)and middle dose group(P<0.01).Both middle and high dose of crude polysaccharide from xigui significantly upregulated thymus and spleen mass and index of mouse(P<0.01).Medium and high dose of crude polysaccharide from xigui significantly reduced the content of BUN in the serum of mice(P<0.01).Middle dose(P<0.01)and high dose(P<0.05)of crude polysaccharide from xigui obviously down-regulated the content of IL-4,increased the content of IFN-γ,and decreased the ratio of IL-4/IFN-γ(P<0.01).Middle dose of drug increased the levels of IgG(P<0.01).Low,medium and high dose of crude polysaccharide from xigui down-regulated liver mass of exercise fatigue mice(P<0.01 or P<0.05),and middle and high dose significantly increased the content of ALB and decreased the content ALT(P<0.05 or P<0.01).Conclusion:By regulating immune function and balance and reducing liver damage,crude polysaccharide from xigui plays an active role in immunomodulation of exercise-induced fatigue. |
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| Keywords: | xigui polysaccharides immune balance exercise-induced fatigue |
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