| 淀粉/PVA膜在血浆模拟液及唾液模拟液中的体外降解行为及相关体外生物相容性评价 |
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| 引用本文： | 石锐,朱爱臣,毕经亮,张立群,陈大福,田伟. 淀粉/PVA膜在血浆模拟液及唾液模拟液中的体外降解行为及相关体外生物相容性评价[J]. 复合材料学报, 2008, 25(6): 1-6 |
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| 作者姓名： | 石锐 朱爱臣 毕经亮 张立群 陈大福 田伟 |
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| 作者单位： | 1. 北京化工大学 北京市新型高分子材料制备与成型加工重点实验室, 北京 100029;2. 北京市创伤骨科组织工程研究所, 北京 100035;3. 北京积水潭医院 北京大学 第四临床医学院脊柱科, 北京 100035 |
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| 基金项目： | 北京自然科学基金重点项目(2061002) |
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| 摘 要： | 通过熔融浇注法制备出一系列厚度在0.05 mm～0.10 mm的淀粉/聚乙烯醇（PVA）（SP）薄膜。研究了薄膜在血浆（SBF）及唾液模拟液（SSF）中的降解行为，分析了降解过程中力学性能、失重率、溶胀度、热性能以及表面形态的变化。研究结果表明，膜在30天的降解过程中能够维持良好的尺寸稳定性和一定的力学强度。通过细胞毒性、细胞贴壁及溶血试验表征了膜的体外生物相容性。结果表明，SP膜具有良好的细胞和血液相容性。所有测试结果证明，SP薄膜是一种应用于诱导组织再生薄膜的潜在材料。
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| 关 键 词： | 淀粉 PVA ? 降解 生物相容性 |
| 收稿时间： | 2008-03-06 |
| 修稿时间： | 2008-06-23 |
In vitro degradation behaviour of starch/PVA films in simulated blood and simulated saliva fluid and in vitro biocompatibility evaluation |
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| SHI Rui,ZHU Aichen,BI Jingliang,ZHANG Liqun,CHEN Dafu,TIAN Wei. In vitro degradation behaviour of starch/PVA films in simulated blood and simulated saliva fluid and in vitro biocompatibility evaluation[J]. Acta Materiae Compositae Sinica, 2008, 25(6): 1-6 |
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| Authors: | SHI Rui ZHU Aichen BI Jingliang ZHANG Liqun CHEN Dafu TIAN Wei |
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| Affiliation: | 1.The Key Laboratory of Beijing City on Preparation and Processing of Novel Polymer Materials, Beijing University of Chemical Technology, Beijing 100029, China;2. Laboratory of Bone Tissue Engineering of Beijing Research Institute of Traumatology and Orthopaedics,Beijing 100035, China;3. Department of Spine Surgery of Beijing Jishuitan Hospital, the Fourth Clinical Medical College of Peking University, Beijing 100035, China |
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| Abstract: | A series of starch/PVA (SP) films with the thickness of 0.05 mm～0.10 mm were casted by the solvent method. The degradation behaviors of the SP films in simulated blood fluid (SBF) and simulated saliva fluid (SSF) were studied. Changes of their mechanical properties, mass loss, swelling degree, thermal properties and morphology of surface during degradation were tested. It is found that the films can keep the shape stability and certain mechanical properties during 30 days degradation. The biocompatibility of the SP film was investigated by cytotoxicity, hemolytic and cell culture tests. The results show that the SP films possess excellent cell and blood compatibility. All the results demonstrate that the SP films can be potentially applied as guide tissue regeneration films. |
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| Keywords: | PVA |
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