| 基于蛋白质哈斯矩阵图的分泌蛋白预测 |
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| 引用本文： | 肖绚,徐培杰. 基于蛋白质哈斯矩阵图的分泌蛋白预测[J]. 计算机工程与应用, 2011, 47(32): 170-172. DOI: 10.3778/j.issn.1002-8331.2011.32.049 |
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| 作者姓名： | 肖绚 徐培杰 |
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| 作者单位： | 景德镇陶瓷学院 机电学院，江西 景德镇 333403 |
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| 基金项目： | 国家自然科学基金No.60961003; 教育部科学技术研究重点项目(No.210116); 江西省自然基金项目(No.2010GQS0127,No.2010GZS0122); 江西省教育厅科研项目(No.GJJ11557)~~ |
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| 摘 要： | 因为研究分泌蛋白质有助于找到直接与特定生理或病理状态相关的生物分子，判断一条未知蛋白是否为分泌蛋白是非常重要的。基于同一类型蛋白质的哈斯矩阵图具有相似图像纹理假设，提取图像的几何矩作为伪氨基酸成分对未知蛋白质序列是否属于分泌蛋白进行预测，采用Jackknife算法进行测试，预测成功率与现有算法相比有很大的提高。
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| 关 键 词： | 分泌蛋白 哈斯矩阵 模糊K近邻算法 Jackknife测试 |
| 修稿时间： | |
Predicting secretory proteins based on protein Hasse matrix image |
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| XIAO Xuan,XU Peijie. Predicting secretory proteins based on protein Hasse matrix image[J]. Computer Engineering and Applications, 2011, 47(32): 170-172. DOI: 10.3778/j.issn.1002-8331.2011.32.049 |
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| Authors: | XIAO Xuan XU Peijie |
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| Affiliation: | School of Mechanical and Electronic Engineering，Jingdezhen Ceramic Institute，Jingdezhen，Jiangxi 333403，China |
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| Abstract: | It is important to identify whether an uncharacterized protein sequence is a secretory proteins or not because secretory proteins are composed with signal peptides which are crucial tool in finding new drugs or reprogramming cells for gene therapy.Based on the assumption that proteins belonging to a same class must bear some sort of similar texture on the protein Hasse matrix images,geometric invariant moment factors derived from the image are used as the pseudo amino acid components to formulate the protei... |
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| Keywords: | secretory proteins Hasse matrix fuzzy K nearest neighbor algorithm Jackknife cross-validation test |
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