A Multifunctional Nanoplatform for Imaging,Radiotherapy, and the Prediction of Therapeutic Response |
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| Authors: | Casey McQuade Ajlan Al Zaki Yaanik Desai Michael Vido Timothy Sakhuja Zhiliang Cheng Robert J. Hickey Daniel Joh So‐Jung Park Gary Kao Jay F. Dorsey Andrew Tsourkas |
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| Affiliation: | 1. Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA;2. Department of Chemistry, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, USA;3. Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA;4. Department of Chemistry and Nano Science, Global Top 5 Program, Ewha Womans University, Seodaemun‐gu, Seoul, Korea |
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| Abstract: | Gold nanoparticles have garnered interest as both radiosensitzers and computed tomography (CT) contrast agents. However, the extremely high concentrations of gold required to generate CT contrast is far beyond that needed for meaningful radiosensitization, which limits their use as combined therapeutic–diagnostic (theranostic) agents. To establish a theranostic nanoplatform with well‐aligned radiotherapeutic and diagnostic properties for better integration into standard radiation therapy practice, a gold‐ and superparamagnetic iron oxide nanoparticle (SPION)‐loaded micelle (GSM) is developed. Intravenous injection of GSMs into tumor‐bearing mice led to selective tumoral accumulation, enabling magnetic resonance (MR) imaging of tumor margins. Subsequent irradiation leads to a 90‐day survival of 71% in GSM‐treated mice, compared with 25% for irradiation‐only mice. Furthermore, measurements of the GSM‐enhanced MR contrast are highly predictive of tumor response. Therefore, GSMs may not only guide and enhance the efficacy of radiation therapy, but may allow patients to be managed more effectively. |
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| Keywords: | gold nanoparticles radiation therapy iron oxide magnetic resonance |
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