Controlled‐release drug carriers based hierarchical silica microtubes templated from cellulose acetate nanofibers |
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| Authors: | Chengying Jia Junlong Song Yongcan Jin Orlando J. Rojas |
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| Affiliation: | 1. Jiangsu Provincial Key Lab of Pulp and Paper Science and Technology, Nanjing Forestry University, Nanjing, China;2. Quzhou Branch of China National Pulp and Paper Research Institute, Quzhou, Zhejiang, China;3. Department of Forest Products Technology, Faculty of Chemistry and Materials Sciences, Aalto University, Aalto, FI, Finland |
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| Abstract: | We report a facile method to synthesize hollow silica microtubes (SMTs) from electrospun cellulose acetate fiber precursors. Specific surface areas of up to 765 m2/g (Brunauer–Emmett–Teller) were measured for the SMTs, which had a typical wall thickness of ～100 nm and submicron inner diameters. An average pore size of 4.6 nm and pore volume of 0.41 cm3/g were derived from Barrett–Joyner–Halenda fitting, whereas Horvath–Kawazoe pore size distribution analysis revealed microporous median pore size and maximum pore volume of 0.7 nm and 0.18 cm3/g, respectively. The as‐prepared SMTs featuring micro‐ and mesoporous structures in the walls where amino‐functionalized to facilitate a very high drug loading (15% by weight). Drug release profile revealed sustained release rates (79% of acetylsalicylic acid was released after 6 h). It is concluded that the high drug loading and sustained release resulted from the advantageous integration of SMTs' hollow structure and wall mesoporosity. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015 , 132, 42562. |
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| Keywords: | applications cellulose and other wood products drug delivery systems electrospinning porous materials |
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