Roles of Albumin‐Binding Proteins in Cancer Progression and Biomimetic Targeted Drug Delivery |
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| Authors: | Pengfei Zhao Yonghui Wang Aihua Wu Prof. Yuefeng Rao Prof. Yongzhuo Huang |
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| Affiliation: | 1. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, P.R. China;2. Zhejiang Academy of Medical Science, Hangzhou, P.R. China;3. The First Affiliated Hospital of the College of Medicine, Zhejiang University, Hangzhou, P.R. China;4. University of Chinese Academy of Sciences, Beijing, P.R. China |
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| Abstract: | Nutrient transporters have attracted significant attention for their promising application in biomimetic delivery. Due to the active consumption of nutrients, cancer cells generally overexpress nutrient transporters to meet their increased need for energy and materials. For example, albumin‐binding proteins (ABPs) are highly overexpressed in malignant cells, stromal cells, and tumor vessel endothelial cells responsible for albumin uptake. ABP (e.g., SPARC) is a promising target for tumor‐specific drug delivery, and albumin has been widely used as a biomimetic delivery carrier. Apart from the transportation function, ABPs are closely associated with neoplasia, invasion, and metastasis. Herein, a summary of the roles of ABP in cancer progression and the application of albumin‐based biomimetic tumor‐targeted delivery through the ABP pathway is presented. |
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| Keywords: | albumin-binding proteins biomimetic delivery cancer drug delivery nutrient transporters |
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