A semi‐adaptive control approach to closed‐loop medication infusion |
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| Authors: | Xin Jin Chang‐Sei Kim Guy A. Dumont J. Mark Ansermino Jin‐Oh Hahn |
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| Affiliation: | 1. Department of Mechanical Engineering, University of Maryland, College Park, MD, USA;2. Department of Electrical and Computer Engineering, University of British Columbia, Vancouver, BC, Canada;3. Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC, Canada |
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| Abstract: | This paper presents a semi‐adaptive control approach to closed‐loop medication infusion problems. The rationale underlying this approach is to design a controller that can adapt model parameters with a large impact on the model's fidelity while fixing the remaining parameters at nominal values. In this paper, a control‐oriented model for this purpose is derived via system identification and sensitivity analysis of a low‐order model capturing the direct dose‐response relationship Using the model thus derived, a model‐reference adaptive controller and a composite adaptive controller are designed and compared with each other. In‐silico simulation results using remifentanil's effect on respiratory rate as an example indicate that both controllers can regulate the output at commanded set points. Copyright © 2016 John Wiley & Sons, Ltd. |
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| Keywords: | semi‐adaptive control medication infusion direct dynamic dose‐response model model‐reference adaptive control composite adaptive control |
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