| 电子加速器生产医用同位素钼-99的发展现状与展望 |
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| 引用本文： | 王怡,郭子方,王兰,李姣龙,焦力敏,高璇,翁汉钦,林铭章. 电子加速器生产医用同位素钼-99的发展现状与展望[J]. 同位素, 2022, 35(2): 114-127. DOI: 10.7538/tws.2022.35.02.0114 |
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| 作者姓名： | 王怡 郭子方 王兰 李姣龙 焦力敏 高璇 翁汉钦 林铭章 |
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| 作者单位： | 中国科学技术大学 核科学技术学院，安徽 合肥230026；中国科学技术大学 国家同步辐射实验室，安徽 合肥230029；北京智博高科生物技术有限公司，北京102502 |
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| 摘 要： | 99 Mo的衰变子体99m Tc是核医学领域中应用最广泛的放射性同位素,近年全球主要的99 Mo生产堆面临着非计划检修及关停退役等问题,导致其供应不稳定,因此多个发达国家已在积极开发99 Mo生产的替代性技术.本文介绍了多种利用粒子加速器代替反应堆生产99 Mo的技术路线,总结了电子加速器生产99 Mo的国内外研究进展...
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| 关 键 词： | 电子加速器 医用同位素 99Mo 99mTc 光核反应 |
Development Status and Prospect for the Medical Isotope Molybdenum-99 Produced by Electron Accelerator |
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| WANG Yi,GUO Zifang,WANG Lan,LI Jiaolong,JIAO Limin,GAO Xuan,WENG Hanqin,LIN Mingzhang. Development Status and Prospect for the Medical Isotope Molybdenum-99 Produced by Electron Accelerator[J]. Isotopes, 2022, 35(2): 114-127. DOI: 10.7538/tws.2022.35.02.0114 |
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| Authors: | WANG Yi GUO Zifang WANG Lan LI Jiaolong JIAO Limin GAO Xuan WENG Hanqin LIN Mingzhang |
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| Affiliation: | School of Nuclear Science and Technology, University of Science and Technology of China, Hefei 230026, China; 2.National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei 230029, China; Beijing Zhibo Bio-medical Technology Co., Ltd, Beijing 102502, China |
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| Abstract: | As the decay daughter of 99Mo, 99mTc is the most widely used radioisotope in the field of nuclear medicine. Recently, the major 99Mo production reactors in the world are facing problems such as unplanned maintenance, shutdown and decommission, resulting in the unstable supply of 99Mo. Therefore, many developed countries have been actively exploiting alternative technologies for 99Mo production. In this paper, various 99Mo-production technologies by particle accelerator instead of reactor were introduced, and the research progress of producing 99Mo based on electron accelerator was summarized at home and abroad. The accelerator performance index and the key technologies in the production process were discussed in detail, such as the design of irradiation device and target, separation of 99mTc, recovery of 100Mo and waste management. In addition, some suggestions were put forward for the basic and applied research of relevant technologies in China and the commercialization of 99Mo production by electron accelerator. |
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| Keywords: | electron accelerator medical isotope 99Mo 99mTc photonuclear reaction |
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