Drug transport in stimuli responsive acrylic and methacrylic interpenetrating polymer networks |
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| Authors: | Marin Simeonov Antonia Monova Bistra Kostova Elena Vassileva |
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| Affiliation: | 1. Laboratory on Structure and Properties of Polymers, Faculty of Chemistry and Pharmacy, University of Sofia, Sofia, Bulgaria;2. Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, Medical University of Sofia, 2, Sofia, Bulgaria |
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| Abstract: | The interpenetrating polymer networks (IPNs) are recently gaining attention as sustained drug delivery systems because they could ensure a proper combination of functionality and network density to control the drug release profiles. This study aims to reveal how the functionality of two IPNs based on polyacrylamide and respectively poly(acrylic acid) (PAA) and poly(methacrylic acid) (PMAA) influences their smart behavior as well as their properties as delivery systems of the cationic drug verapamil hydrochloride (VPM). The “extra” α‐methyl group of PMAA results into a loss of the temperature sensitivity in the studied region and changes the pH responsivity of the PMAA/PAAM IPNs as compared to the PAA/PAAM IPNs. Moreover, the VPM diffusion in both IPNs depends on their composition due to the change in their functionality as well as of their network density. The “extra” α‐methyl group of PMAA defines its enhanced hydrophobicity and hence influences the VPM diffusion mechanism. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017 , 134, 45380. |
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| Keywords: | drug delivery systems gels stimuli‐sensitive polymers swelling |
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