| 金属有机骨架材料载体用于酶固定化的研究进展 |
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| 引用本文： | 范铮,唐咸昌,张旭,李畅,张国亮. 金属有机骨架材料载体用于酶固定化的研究进展[J]. 化工进展, 2019, 38(10): 4606-4613. DOI: 10.16085/j.issn.1000-6613.2018-2451 |
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| 作者姓名： | 范铮 唐咸昌 张旭 李畅 张国亮 |
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| 作者单位： | 浙江工业大学海洋学院,绿色化学国家重点实验室培育基地,浙江杭州310014;浙江工业大学海洋学院,绿色化学国家重点实验室培育基地,浙江杭州310014;浙江工业大学海洋学院,绿色化学国家重点实验室培育基地,浙江杭州310014;浙江工业大学海洋学院,绿色化学国家重点实验室培育基地,浙江杭州310014;浙江工业大学海洋学院,绿色化学国家重点实验室培育基地,浙江杭州310014 |
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| 基金项目： | 国家自然科学基金(21736009);浙江省科技计划(GF19B070015) |
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| 摘 要： | 现有的固定化酶技术存在低稳定性、低回收利用率等缺点，而金属有机骨架材料（MOFs）凭借自身独特的性质如特定的主-客体相互作用及限域效应，极大提高了酶的负载率以及限制酶分子的流失，甚至极端环境下仍能维持酶的活性，近年来成为固定化酶载体的研究热点。本文从酶-MOF复合物的合成策略出发，介绍了利用MOFs载体完成酶固定化包括表面吸附、共价结合、孔道包埋和原位合成这4种方法的优劣势，重点概述了酶-MOF复合物在微反应器构建、级联反应等应用领域的巨大潜力。研究进展表明，有巨大优势的新型MOFs载体将有力促进酶-MOF复合物作为优异的催化剂、生物传感器等在多学科领域的发展。
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| 关 键 词： | 金属有机骨架材料 酶 固定化 合成策略 |
| 收稿时间： | 2018-12-21 |
Progress of on enzyme immobilization with metal-organic frameworks |
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| Zheng FAN,Xianchang TANG,Xu ZHANG,Chang LI,Guoliang ZHANG. Progress of on enzyme immobilization with metal-organic frameworks[J]. Chemical Industry and Engineering Progress, 2019, 38(10): 4606-4613. DOI: 10.16085/j.issn.1000-6613.2018-2451 |
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| Authors: | Zheng FAN Xianchang TANG Xu ZHANG Chang LI Guoliang ZHANG |
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| Affiliation: | State Key Lab Breeding Base of Green Chemical Synthesis Technology, Institute of Oceanic and Environmental Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, Zhejiang, China |
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| Abstract: | The existing immobilized enzyme technologies (mainly the ill-developed carriers) have limitations of low stability and/or low recovery rate. Metal-organic frameworks (MOFs) are considered as the most promising carriers for enzyme immobilization due to their unique properties such as specific host-guest interaction and confinement effect, which can greatly keep enzymes with high loading, low leaching and comparable catalytic efficiency under harsh conditions. In this review, four kinds of efficient synthesis strategies including surfaces adsorption, covalent binding, cage inclusion and in-situ synthesis are introduced and compared. Moreover, the potential applications of enzyme-MOF composites in micro-reactor design, cascade reaction and other fields are discussed. The research progresses indicate that the huge merits of MOFs carriers will synergistically promote the development of enzyme-MOF composites as catalyst and bio-sensor in multi-disciplinary fields. |
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| Keywords: | metal-organic frameworks (MOFs) enzyme immobilization synthetic strategie |
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