| 热熔挤出中吲哚美辛熔化和混合机理的研究 |
| |
| 引用本文： | 陈佳楠,李翱. 热熔挤出中吲哚美辛熔化和混合机理的研究[J]. 中国塑料, 2018, 32(9): 90-95. DOI: 10.19491/j.issn.1001-9278.2018.09.015 |
| |
| 作者姓名： | 陈佳楠 李翱 |
| |
| 作者单位： | 北京化工大学机电工程学院 |
| |
| 摘 要： | 选用难溶性药物吲哚美辛（INM）为模型药物，泊洛沙姆188（F-68）为载体，从数值模拟和实验研究2方面研究采用双转子混合器制备F-68/INM固体分散体过程中，转子速比对INM熔化相变和混合过程的影响规律。结果表明，提高转子速比，INM在载体F-68中的分布、分散混合和熔化扩散作用均得到增强，INM的溶出进程加快。
|
| 收稿时间： | 2018-03-21 |
Study on Melting and Mixing Mechanism of Indomethacin in Hot-melt Extrusion |
| |
| Abstract: | The insoluble drug indomethacin (INM) and poloxamer 188 was used as a model drug and a carrier, respectively, and a solid dispersion of indomethacin and poloxamer 188 was prepared by a twin rotor mixer. The effect of rotor speed ratio on the melt transition and mixing process of INM was studied in terms of the two aspects of numerical simulation and experimental investigation. The results indicated that the distribution, dispersion mixing and melt diffusion of INM in the carrier could be enhanced by increasing the rotor speed ratio, and the dissolution process of INM was also accelerated. |
| |
| Keywords: | |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《中国塑料》浏览原始摘要信息 |
|
点击此处可从《中国塑料》下载全文 |
|
