| 大果沙棘黄酮对四氧嘧啶所致糖尿病小鼠血糖水平的影响 |
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| 引用本文： | 伊娟娟, 王振宇, 白海娜, 左丽丽, 高季瑜. 大果沙棘黄酮对四氧嘧啶所致糖尿病小鼠血糖水平的影响[J]. 食品工业科技, 2014, (06): 347-350. DOI: 10.13386/j.issn1002-0306.2014.06.084 |
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| 作者姓名： | 伊娟娟 王振宇 白海娜 左丽丽 高季瑜 |
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| 摘 要： | 目的:研究大果沙棘黄酮对四氧嘧啶(ALX)诱导的糖尿病小鼠的血糖水平的影响。方法:用ALX制造糖尿病小鼠模型,大果沙棘总黄酮(BFH)及各流段黄酮BFHⅠ、BFHⅡ、BFHⅢ均分为对照组、模型组、低、中、高剂量组,每天一次性灌胃,连续灌胃4周。结果:与模型组相比,BFH及BFHⅠ、BFHⅡ、BFHⅢ均能显著地降低ALX诱导的糖尿病小鼠血糖水平和尿素氮(BUN)含量,提高胰岛素水平、肝(肌)糖元含量,同时也可提高糖尿病小鼠的麦芽糖酶水平。结论:大果沙棘总黄酮和纯化后的三个流份均能有效的控制糖尿病小鼠血糖水平,有望开发成安全有效的降糖产品。
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| 关 键 词： | 沙棘黄酮 四氧嘧啶 糖尿病 血糖 |
| 收稿时间： | 2013-07-08 |
Hpyerglycemic of flavonoids and various components from Hippophae rhamnoides L. in ICR mice with alloxan induced diabetes |
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| YI Juan-juan, WANG Zhen-yu, BAI Hai-na, ZUO Li-li, GAO Ji-yu. Hpyerglycemic of flavonoids and various components from Hippophae rhamnoides L. in ICR mice with alloxan induced diabetes[J]. Science and Technology of Food Industry, 2014, (06): 347-350. DOI: 10.13386/j.issn1002-0306.2014.06.084 |
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| Authors: | YI Juan-juan WANG Zhen-yu BAI Hai-na ZUO Li-li GAO Ji-yu |
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| Affiliation: | 1.School of Food Science and Engineering, Harbin Institute of Technology;2.School of Forestry, Northeast Forestry University |
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| Abstract: | Objective:To examine the potential hpyerglycemic of flavonoids from sea buckthorn (Hippophae rhamnoides L.) BFH and each flow period of flavonoids BFH Ⅰ, BFH Ⅱ, BFH Ⅲ different dose groups in ICR mice with diabetes healthy IR mice were used as experiment animals to create an alloxan (ALX) induced diabetic model. Methods:Mice with ALX induced diabetes were randomly divided into 4 groups including model control group administered normal saline by adiministration and BFH and BFH Ⅰ, BFH Ⅱ, BFH Ⅲdifferent dose groups all administered control group, model control group, low, medium and high doses groups.All the groups were administered once a day for 4 consecutive weeks. Results:Compared to the control group, the BFH, BFH Ⅰ, BFH Ⅱand BFH Ⅲ groups could lowered the level of serum glucose and BUN significantly, and elevated insulin, glycogen and maltase levels. Conclusion:The BFH and BFH Ⅰ, BFH Ⅱ, BFH Ⅲ different dose groups not only effectively regulates the levels of serum glucose, but also was expected to develop into a safe and effective hypoglycemic products. |
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| Keywords: | flavonoids from sea buckthorn alloxan (ALX) diabetes serum glucose |
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