Injectable Granular Hydrogels with Multifunctional Properties for Biomedical Applications |
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| Authors: | Joshua E. Mealy Jennifer J. Chung David Issadore Daeyeon Lee Pavan Atluri Jason A. Burdick |
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| Affiliation: | 1. Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA;2. Division of Cardiovascular Surgery, University of Pennsylvania, Philadelphia, PA, USA;3. Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA, USA |
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| Abstract: | Injectable hydrogels are useful for numerous biomedical applications, such as to introduce therapeutics into tissues or for 3D printing. To expand the complexity of available injectable hydrogels, shear‐thinning and self‐healing granular hydrogels are developed from microgels that interact via guest–host chemistry. The microgel properties (e.g., degradation, molecule release) are tailored through their crosslinking chemistry, including degradation in response to proteases. When microgels of varied formulations are mixed, complex release and degradation behaviors are observed, including after injection to permit cellular invasion. |
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| Keywords: | biomaterials drug delivery hydrogels microfluidics microgels |
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