A Magnetofluorescent Carbon Dot Assembly as an Acidic H2O2‐Driven Oxygenerator to Regulate Tumor Hypoxia for Simultaneous Bimodal Imaging and Enhanced Photodynamic Therapy |
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| Authors: | Qingyan Jia Jiechao Ge Weimin Liu Xiuli Zheng Shiqing Chen Yongmei Wen Hongyan Zhang Pengfei Wang |
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| Affiliation: | 1. Key Laboratory of Photochemical Conversion and Optoelectronic Materials and CityU‐CAS Joint Laboratory of Functional Materials and Devices, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, P. R. China;2. School of Future Technology, University of Chinese Academy of Sciences, Beijing, China |
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| Abstract: | Recent studies indicate that carbon dots (CDs) can efficiently generate singlet oxygen (1O2) for photodynamic therapy (PDT) of cancer. However, the hypoxic tumor microenvironment and rapid consumption of oxygen in the PDT process will severely limit therapeutic effects of CDs due to the oxygen‐dependent PDT. Thus, it is becoming particularly important to develop a novel CD as an in situ tumor oxygenerator for overcoming hypoxia and substantially enhancing the PDT efficacy. Herein, for the first time, magnetofluorescent Mn‐CDs are successfully prepared using manganese(II) phthalocyanine as a precursor. After cooperative self‐assembly with DSPE‐PEG, the obtained Mn‐CD assembly can be applied as a smart contrast agent for both near‐infrared fluorescence (FL) (maximum peak at 745 nm) and T1‐weighted magnetic resonance (MR) (relaxivity value of 6.97 mM?1 s?1) imaging. More interestingly, the Mn‐CD assembly can not only effectively produce 1O2 (quantum yield of 0.40) but also highly catalyze H2O2 to generate oxygen. These collective properties of the Mn‐CD assembly enable it to be utilized as an acidic H2O2‐driven oxygenerator to increase the oxygen concentration in hypoxic solid tumors for simultaneous bimodal FL/MR imaging and enhanced PDT. This work explores a new biomedical use of CDs and provides a versatile carbon nanomaterial candidate for multifunctional nanotheranostic applications. |
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| Keywords: | acidic H2O2‐driven oxygenerator bimodal imaging carbon dot photodynamic therapy tumor hypoxia |
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