| 2,3-丁二醇的发酵生产 |
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| 引用本文： | 宋源泉,许赟珍,李强,刘德华. 2,3-丁二醇的发酵生产[J]. 化工进展, 2011, 30(5): 1069-1077 |
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| 作者姓名： | 宋源泉 许赟珍 李强 刘德华 |
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| 作者单位： | 清华大学化学工程系，北京 100084 |
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| 摘 要： | 能源危机和环境污染使得化工行业的发展举步维艰，亟待开发新的发展模式，以可再生能源为原料的生物炼制技术成为可行的途径之一。2,3-丁二醇的发酵生产是现代生物炼制的重要课题之一。2,3-丁二醇作为一种大宗的化学产品具有广泛的应用价值，尤其在化工、食品、燃料、医药等领域。本文简要描述了2,3-丁二醇在微生物体内的代谢途径，着重讨论了2,3-丁二醇的发酵生产，对发酵的菌种种类、菌种诱变和定向改造、各种发酵影响因素（包括底物、pH值、溶氧、温度以及发酵方式）进行了详细的归纳总结，同时展望了2,3-丁二醇发酵生产的研究发展方向。
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| 关 键 词： | 2,3-丁二醇 发酵生产 生物炼制 |
Fermentation of bio-based product 2,3-butanediol |
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| SONG Yuanquan,XU Yunzhen,LI Qiang,LIU Dehua. Fermentation of bio-based product 2,3-butanediol[J]. Chemical Industry and Engineering Progress, 2011, 30(5): 1069-1077 |
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| Authors: | SONG Yuanquan XU Yunzhen LI Qiang LIU Dehua |
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| Affiliation: | Department of Chemical Engineering，Tsinghua University，Beijing 100084，China |
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| Abstract: | The development of chemical industry is hindered by energy crisis and environment pollution，and a new model of development is urgently to be exploited. Biorefining technology with renewable resources as feedstock is proposed as one possible solution，in which 2,3-butanediol fermentation is one important issue. 2,3-Butanediol，a bulk chemical product，has extensive applications，especially in chemical processes，food，fuel and medicine. The metabolic pathway of 2,3-butanediol is briefly described，and the progress of biotechnological production of 2,3-butanediol is reviewed，including microbial strains，strains mutagenization，genetic modifications and operating conditions (substrates，pH value，aeration，temperature and fermentation mode). Finally，2,3-butanediol fermentation research directions are proposed. |
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