Synthesis of Ecofriendly Functionalized Oxadiazole,Imidazole, Triazole and Pyridine Derivatives |
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| Authors: | Refat El-Sayed Amani Shaldom Layla Al Mazrouee |
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| Affiliation: | 1.Chemistry Department, College of Applied Sciences,Umm Al-Qura University,Makkah,Saudi Arabia;2.Chemistry Department, Faculty of Science,Benha University,Benha,Egypt |
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| Abstract: | 5-Pentadecyl-1,3,4-oxadiazol-2-amine (2) was employed as key intermediate for the synthesis of some new functionalized five and six membered heterocyclic derivatives. The synthesized compounds were reacted with propylene oxide to obtain surface active agents having good surface activity, high solubility in water and good biodegradability. Moreover, the functionalized surfactants showed good antimicrobial activity against gram negative and gram positive organisms. The new compounds are easily synthesized, economical and environmentally friendly and are expected to constitute an important class of organic compounds for medicinal purposes in the future. |
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| Keywords: | Synthesis Heterocyclic derivatives Antimicrobial and surface activities |
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