| 利培酮联合抗抑郁药物治疗抑郁症对照研究的 Meta 分析 |
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| 引用本文： | 金卫东,陈炯,唐贤祥,邢葆平. 利培酮联合抗抑郁药物治疗抑郁症对照研究的 Meta 分析[J]. 金属学报, 2005, 10(11): 1299-1303 |
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| 作者姓名： | 金卫东 陈炯 唐贤祥 邢葆平 |
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| 作者单位： | 浙江省立同德医院、浙江省精神卫生研究院,杭州 310012,浙江 |
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| 摘 要： | 目的: 评价利培酮联合抗抑郁药物与抗抑郁药物单一治疗抑郁症的有效性与安全性的差异。方法: 应用循证医学方法对符合标准的10项研究进行分析,评价利培酮联合抗抑郁药物与抗抑郁药物单一治疗抑郁症的疗效、效应大小、痊愈率以及副作用的差异。结果: 同质性检验:(1)有效性:χ2=7.26,df=9(P>0.05);(2)安全性:χ2=3.41,df=2(P>0.05)。综合检验:研究组与对照组在第1、2、4、6、8周末的综合检验分别为Z1=14.19(P<0.01)、Z2=14.00(P<0.01)、Z4=17.40(P<0.01)、Z6=12.10(P<0.01)、Z8=5.94(P<0.01)。效应大小:无论是研究组还是对照组,在第1、2、4、6、8周末与治疗前进行比较的治疗效应大多数达到0.5以上;研究组与对照组干预处理效应的差异效应在不同时段的差异效应都大于0.8。有效性比较:应用固定效应模型或随机效应模型显示研究组所有时段痊愈率、显效率均非常显著高于对照组,而无效率低于对照组(8周末除外)。副作用:两组之间的副作用差异没有显著性(Z=0.20~1.15,P>0.05)。结论: 小剂量利培酮联合抗抑郁药物治疗抑郁症是一种良好的方法,可能特别适宜于难治性抑郁症。
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| 关 键 词： | 利培酮 抗抑郁药物 抑郁症 有效性 安全性 Meta分析 循证医学 |
| 收稿时间： | 2005-08-12 |
| 修稿时间： | 2005-08-12 |
Meta-analysis of efficacy of risperidone in combination with antidepressant and single antidepressant in treatment of depression |
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| JIN Wei-dong,CHEN Jiong,TANG Xian-xiang,XING Bao-ping. Meta-analysis of efficacy of risperidone in combination with antidepressant and single antidepressant in treatment of depression[J]. Acta Metallurgica Sinica, 2005, 10(11): 1299-1303 |
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| Authors: | JIN Wei-dong CHEN Jiong TANG Xian-xiang XING Bao-ping |
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| Affiliation: | Zhejiang Province Tongde Hospital & Zhejiang Province Mental Health Institute,310012,Hangzhou,Zhejiang,China |
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| Abstract: | AIM: to assess the differences in efficacy and safety between risperidone combing antidepressants and single antidepressant in treatment of depression.METHODS: 10 studies meeting ourcriteria were ana-lyzed by based-evidence medicine,comparing the differ-ence in efficacy,effect size(ES),full remission rate and side effects.RESULTS: Hoterogenity test:(1)efficacy,χ2=7.26,df=9,P>0.05;(2)safety,χ2=3.41,df=2,P>0.05.Comprehensive test:the comprehensive testing result between two groups at 1st,2nd,4th,6th,8th weekend were as following:Z1=14.19,P<0.01;Z2=14.00,P<0.01;Z4=17.40,P<0.01;Z6=12.10,P<0.01;Z8=5.94,P<0.01.3.Effect size(ES):The effect size of two groups at 1st,2nd,4th,·1302·Chin J Clin Pharmacol Ther2005 Nov;10(11)6th,8th weekend are all respectively more than 0.5,and intervening effect size between two groups all more than 0.8.4.Efficacy:The full remission rate and significant effective rate of studying groups by fixed effect model and random effect model were highersignificantly than that of control groups,and ineffective rate were significantly low-erthan that of control groups.4.Side effect:No differ-ence in side effects between two groups was found(Z =0.20-1.15,P>0.05).CONCLUSION: It is a bettertherapy of patients with depression,especially treatment-resistant depression,combining antidepressants with lowerdosage of risperidone. |
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| Keywords: | Antidepressant Depression Efficacy Safety Meta-analysis Evidence-based Medication Risper-idone |
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