Study of morphological and mechanical features of multinuclear and mononuclear SW480 cells by atomic force microscopy |
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| Authors: | Jinyun Liu Yingmin Qu Guoliang Wang Xinyue Wang Wenxiao Zhang Jingmei Li Zuobin Wang Dayou Li Jinlan Jiang |
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| Affiliation: | 1. International Research Centre for Nano Handling and Manufacturing of China, Changchun University of Science and Technology, Changchun, 130022, China;2. Institute for Research in Applicable Computing, University of Bedfordshire, Luton, LU1 3JU, United Kingdom;3. Scientific Research Centre of China‐Japan Union Hospital, Jilin University, Changchun, 130033, China |
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| Abstract: | This article studies the morphological and mechanical features of multinuclear and mononuclear SW480 colon cancer cells by atomic force microscopy to understand their drug‐resistance. The SW480 cells were incubated with the fullerenol concentrations of 1 mg/ml and 2 mg/ml. Morphological and mechanical features including the height, length, width, roughness, adhesion force and Young's modulus of three multinuclear cell groups and three mononuclear cell groups were imaged and analyzed. It was observed that the features of multinuclear cancer cells and mononuclear cancer cells were significantly different after the treatment with fullerenol. The experiment results indicated that the mononuclear SW480 cells were more sensitive to fullerenol than the multinuclear SW480 cells, and the multinuclear SW480 cells exhibited a stronger drug‐resistance than the mononuclear SW480 cells. This work provides a guideline for the treatments of multinuclear and mononuclear cancer cells with drugs. |
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| Keywords: | atomic force microscope mechanical features mononuclear cells morphological features multinuclear cells |
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