| 磺基甜菜碱的合成研究进展 |
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| 引用本文： | 牛瑞霞,任伟东,孙双波,宋华,李征鸿. 磺基甜菜碱的合成研究进展[J]. 化工进展, 2013, 32(8): 1887-1892 |
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| 作者姓名： | 牛瑞霞 任伟东 孙双波 宋华 李征鸿 |
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| 作者单位： | 1.东北石油大学化学化工学院，石油与天然气化工省高校重点实验室，黑龙江 大庆 163318；2大庆油田有限责任公司天然气分公司，黑龙江 大庆 163500 |
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| 摘 要： | 磺基甜菜碱具有性能温和、界面活性高、抗二价阳离子能力强等优点，被广泛应用于洗涤剂、化妆品、石油开采等领域。本文介绍了以胺为原料，经叔胺化-季铵化两步法合成磺基甜菜碱的合成工艺进展，重点阐述了制备叔胺中间体的4种方法，即卤化胺化法、醇一步催化胺化法、甲醛加氢法和羰基还原胺化法。从原料性能、收率、环保性、可操作性等方面进行了分析比较，讨论了各方法存在的问题及工业化的可行性。此外，对叔胺中间体的季铵化过程中所用试剂3-氯-2-羟基丙磺酸钠和磺酸内酯进行了比较，最后指出羰基还原胺化法是实现绿色工业化生产应该努力的方向，而3-氯-2-羟基丙磺酸钠是一种经济、绿色、环保的季铵化试剂。
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| 关 键 词： | 磺基甜菜碱 羰基还原胺化 合成 磺基甜菜碱 羰基还原胺化 合成 |
Research progress in the synthesis of sulphobetaine |
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| NIU Ruixia , REN Weidong , SUN Shuangbo , SONG Hua , LI Zhenghong. Research progress in the synthesis of sulphobetaine[J]. Chemical Industry and Engineering Progress, 2013, 32(8): 1887-1892 |
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| Authors: | NIU Ruixia REN Weidong SUN Shuangbo SONG Hua LI Zhenghong |
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| Affiliation: | 1 Provincial Key Laboratory of Oil & Gas Chemical Technology，College of Chemistry ＆ Chemical Engineering，Northeast Petroleum University，Daqing 163318，Heilongjiang，China；2 Natural Gas Branch of Daqing Oilfield Limited Company，Daqing 163500，Heilongjiang，China |
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| Abstract: | Sulphobetaine is widely used in the fields of detergent，cosmetic and oil recovery because of its mildness，high interfacial activity，and strong capacity for tolerating the divalent cations，and so on. In this paper，the progress in the two-step synthesis technology of sulphobetaine using amine as raw material is discussed，four methods to produce the intermidate (tertiary amine) were described particularly，including halogenate-amination，catalytic amination of alcohols，formaldehyde hydrogenation and reductive amination of carbonyl compounds. The problem and the industrialization feasibility of each synthesis technology were discussed in terms of raw materials，yield，environmental protection property and practicalities. Besides，sodium 3-chloro-2-hydroxy propanesulfonate and propane sultone used in the quaterisation of tertiary amine were compared in detail. It can be concluded that the further research shall be focused on the reductive amination of carbonyl compounds for its green property. 3-Chloro-2-hydroxy propanesulfonate is a good reagent for quaterisation. |
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| Keywords: | sulphobetaine reductive amination of carbonyl compounds synthesis |
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