Complex aggregates formed with a hyperbranched polyglycerol derivative for drug delivery |
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| Authors: | Qianqian Zheng Xiaoyan Zhou Hui Li Dong Ma Wei Xue |
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| Affiliation: | 1. Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, Jinan University, Guangzhou, China;2. Institute of Life and Health Engineering, Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Jinan University, Guangzhou, China |
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| Abstract: | An amphiphilic hyperbranched polyglycerol derivative (HPG‐C18) was synthesized by the anionic ring‐opening copolymerization with glycidol and 1,2‐epoxyloctadecane as the monomers. This hyperbranched polymer formed large complex aggregates as confirmed by dynamic light scattering and transmission electron microscopy tests. Because of its amphiphilic properties, HPG‐C18 was explored to load hydrophobic docetaxel, a clinical antitumor drug, and deliver it into breast cancer cell line (MCF‐7) cells. To investigate the application of the aggregates in drug delivery, blood compatibility was studied by hemolysis analysis, red blood cell observation, and thromboelastography assay. These results indicate that HPG‐C18 inhibited MCF‐7 proliferation effectively with good blood compatibility, and this suggested a potential application in tumor therapy. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016 , 133, 42895. |
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| Keywords: | biocompatibility drug‐delivery systems micelles |
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