| 薯蓣粥对T2DM大鼠肠道微生物、血糖、胰岛素的影响 |
| |
| 引用本文： | 洪雪珮,庞书勤,周建,陈芳,罗宗婷,张佳惠. 薯蓣粥对T2DM大鼠肠道微生物、血糖、胰岛素的影响[J]. 食品工业科技, 2021, 42(14): 341-347. DOI: 10.13386/j.issn1002-0306.2020090192 |
| |
| 作者姓名： | 洪雪珮 庞书勤 周建 陈芳 罗宗婷 张佳惠 |
| |
| 作者单位： | 福建中医药大学护理学院,福建福州 350122 |
| |
| 基金项目： | 福建省自然科学基金项目（2017J01833）;福建中医药大学校管护理学科开放课题（X2019040） |
| |
| 摘 要： | 目的:探讨薯蓣粥对2型糖尿病(type 2 diabetes mellitus,T2DM)大鼠肠道微生物、短链脂肪酸(short-chain fatty acids,SCFAs)血糖、胰岛素分泌的影响.方法:将60只SPF级Wister大鼠随机抽取10只为空白组,剩余50只腹部注射链脲佐菌素(STZ)制作T2DM模型,...
|
| 关 键 词： | 薯蓣粥 2型糖尿病 肠道菌群 短链脂肪酸 16S-rDNA测序 |
| 收稿时间： | 2020-09-18 |
Effects of Yam Gruel on Gut Microflora,Blood Glucose and Insulin in T2DM Rats |
| |
| HONG Xuepei,PANG Shuqin,ZHOU Jian,CHEN Fang,LUO Zongting,ZHANG Jiahui. Effects of Yam Gruel on Gut Microflora,Blood Glucose and Insulin in T2DM Rats[J]. Science and Technology of Food Industry, 2021, 42(14): 341-347. DOI: 10.13386/j.issn1002-0306.2020090192 |
| |
| Authors: | HONG Xuepei PANG Shuqin ZHOU Jian CHEN Fang LUO Zongting ZHANG Jiahui |
| |
| Affiliation: | School of Nursing, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China |
| |
| Abstract: | Objective: To investigate the effect of yam gruel on gut microflora, short chain fatty acids (SCFAs), blood glucose and insulin secretion in type 2 diabetic rats. Methods: 60 SPF Wister rats were randomly selected as blank group, and the remaining 50 rats were injected with streptozotocin (STZ) to make T2DM model. The rats were randomly divided into model group, yam gruel group, metformin group and combination group. The blank group and model group were given 5 mL normal saline, the yam gruel group was given 5 mL yam gruel every day, the metformin group was given metformin aqueous solution every day, and the combination group was given yam gruel and metformin for six weeks. The fasting blood glucose (FBG) of rats was detected every week. After the intervention, the blood glucose, fasting insulin (FINS), gut microflora composition and the content of SCFAs in feces were detected. Results: Compared with the blank group, the FBG, FINS and insulin resistance index of the model group were increased (P<0.05), the contents of acetic acid, propionic acid, butyric acid, OTUs, Chao1 index and Shannon index were significantly decreased (P<0.05), the relative abundance of Firmicutes, Verrucomicrobia, Oscellospira, Akkermansia and Clostridium decreased (P<0.05), and the relative abundance of Proteobacteria increased (P<0.05). After 4 weeks of intervention, blood glucose of rats in Yam gruel group decreased significantly (P<0.05). The FBG, FINS and HOMA-IR of the yam gruel group were significantly lower than those of model group (P<0.05). The FINS and HOMA-IR of the yam gruel group were no significant difference between metformin group, combination group. Compared with the model group, the contents of acetic acid, propionic acid and butyric acid of the yam gruel group increased (P<0.01), the OTUs, Firmicutes, Verrucomicrobia, Akkermansia and Clostridium of the yam gruel group increased, and Proteobacteria of the yam gruel group decreased (P<0.05). Conclusion: Yam gruel might improve insulin resistance and reduce blood glucose by improving intestinal microbial imbalance and increasing SCFAs content in T2DM rats. |
| |
| Keywords: | |
|
| 点击此处可从《食品工业科技》浏览原始摘要信息 |
|
点击此处可从《食品工业科技》下载全文 |
|
