| 基于三维打印骨支架制备及其性能 |
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| 引用本文： | 汪焰恩,潘飞龙,杨明明. 基于三维打印骨支架制备及其性能[J]. 化工进展, 2013, 32(12): 2940 |
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| 作者姓名： | 汪焰恩 潘飞龙 杨明明 |
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| 作者单位： | 西北工业大学机电学院，陕西 西安 710072 |
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| 摘 要： | 利用三维打印（3DP）成型技术制备了羟基磷灰石（HAP）支架与混合壳聚糖（CS）的HAP-CS复合支架，并用Ⅰ型胶原蛋白（Collagen TypeⅠ）对HAP-CS支架进行了改性处理；通过抗压强度实验、孔隙率测定、微观形貌观察、亲水性及碱性磷酸酶（ALP）活性检测实验研究了所制备支架性能。结果表明添加CS可提高HAP支架抗压强度74.5%，但未降低支架孔隙率；经Collagen Type I改性的HAP-CS支架的亲水性有显著提高，ALP活性检测结果显示Collagen Type Ⅰ可提高细胞骨化能力。综上，本研究所制备的HAP-CS改性支架具有良好的性能及生物活性，可用于骨缺损修复研究。
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| 关 键 词： | 三维打印 支架 壳聚糖 Ⅰ型胶原蛋白 |
Research on the preparation of bone scaffold based on three dimensional printing and its properties |
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| WANG Yan’en,PAN Feilong,YANG Mingming. Research on the preparation of bone scaffold based on three dimensional printing and its properties[J]. Chemical Industry and Engineering Progress, 2013, 32(12): 2940 |
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| Authors: | WANG Yan’en PAN Feilong YANG Mingming |
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| Affiliation: | Mechatronics School，Northwestern Polytechnical University，Xi’an 710072，Shaanxi，China |
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| Abstract: | Hydroxyapatite (HAP) scaffold and hydroxyapatite/chitosan (HAP-CS) composite scaffold mixed with chitosan were prepared using three dimensional printing (3DP) manufacturing technology. And HAP-CS scaffold was modified with Collagen TypeⅠ. Properties of the prepared scaffolds have been studied through compressive strength experiment，porosity measurement，micro morphology observation，hydrophily and alkaline phosphatase (ALP) activity experiment. The results demonstrated that CS could result in a 74.5% improvement of compressive strength of HAP scaffold，while the porosity of scaffold was not decreased. The hydrophily of HAP-CS scaffold modified with Collagen Type Ⅰ was significantly enhanced. ALP activity experiment results indicated that Collagen Type Ⅰ could improve the ossification ability of cell on the HAP-CS scaffold. Excellent structural properties and biological activity have been observed from the HAP-CS scaffold modified with Collagen Type Ⅰ ，which could be used for the research of bone defect repair. |
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| Keywords: | three dimensional printing scaffold chitosan collagen type I |
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