Effects of axial circulation and dispersion geometry on the scale‐up of ultrasonic extraction of polysaccharides |
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| Authors: | Ibrahim Alzorqi Sivakumar Manickam |
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| Affiliation: | Manufacturing and Industrial Processes Research Division, University of Nottingham Malaysia Campus, Faculty of Engineering, Semenyih, Selangor D.E.,, Malaysia |
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| Abstract: | The ultrasonic‐assisted extraction of polysaccharides (PS) from Ganoderma lucidum, was subjected to a scale‐up study. 0.25 L extractor was used to optimize the extraction conditions toward maximum yield of PS. The extracted PS was observed to be reduced by increasing the scale from 1 to 6 L. To intensify the extraction, axial circulation at different stirring rates was induced and optimized in a 3 L U‐tube extractor. Although circulation at 300 rpm improved the yield of PS for 3 L, introducing dispersion geometry (conical funnel) and adjusting the radiation distance in a 6 L U‐tube extractor further intensified the extraction efficiency. A radiation distance of 4 cm and circulation induced using 600 rpm enhanced the PS as compared to the conventional 6 L extractor. Overall, the scale‐up from 0.25 to 6 L was successful and introducing circulation and dispersion geometry intensified the extraction efficiency under similar dissipation of ultrasonic power. © 2015 American Institute of Chemical Engineers AIChE J, 61: 1483–1491, 2015 |
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| Keywords: | ultrasound cavitation extraction scale‐up circulation polysaccharides |
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