| 贝那普利前体的制备 |
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| 引用本文： | 王涛,王芳,万平玉,WAN Pingyu. 贝那普利前体的制备[J]. 化工学报, 2007, 58(10): 2558-2560 |
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| 作者姓名： | 王涛 王芳 万平玉 WAN Pingyu |
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| 作者单位： | 北京化工大学 |
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| 摘 要： | 本文采用两种过程制备盐酸贝那普利的前体[3-[(1-乙氧羰基-3-苯基丙基)-氨基]-2,3,4,5-四氢-2-氧代-1-H-1-苯并氮杂卓-1-乙酸叔丁酯(EPTAB)，并优化了其制备条件。异构体的分离采用柱层析分离。产品结构采用IR和NMR表征。
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| 关 键 词： | 盐酸贝那普利 EPTAB 合成 |
| 文章编号： | 0438-1157（2007）10-2558-03 |
| 收稿时间： | 2007-03-27 |
| 修稿时间： | 2007-03-27 |
New process for preparing benazepril precursor |
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| Kafssi Hassan,WANG Tao,WANG Fang,WAN Pingyu. New process for preparing benazepril precursor[J]. Journal of Chemical Industry and Engineering(China), 2007, 58(10): 2558-2560 |
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| Authors: | Kafssi Hassan WANG Tao WANG Fang WAN Pingyu |
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| Affiliation: | Department of Chemistry, Beijing University of Chemical Technology, Beijing 100029, China;Department of Chemistry, Beijing University of Chemical Technology, Beijing 100029, China;Department of Chemistry, Beijing University of Chemical Technology, Beijing 100029, China;Department of Chemistry, Beijing University of Chemical Technology, Beijing 100029, China |
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| Abstract: | The present work relates to a new synthesis process for the preparation of 3-[(1-ethoxycarbonyl-3-phenylpropyl) -amino ] -2, 3, 4, 5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetate tert butyl ester (EPTAB), the precursor of benazepril HCl. The reaction conditions were optimized. The diastereomeric products were separated by flash column chromatography. The structures of the products were characterized with IR and NMR. |
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| Keywords: | benazepril HCl EPTAB preparation |
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