Critical update on 2‐methacryloyloxyethyl phosphorylcholine (MPC) polymer science |
| |
| Authors: | Tatsuro Goda Kazuhiko Ishihara Yuji Miyahara |
| |
| Affiliation: | 1. Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Chiyoda, Tokyo, Japan;2. Department of Materials Engineering, The University of Tokyo, Bunkyo, Tokyo, Japan;3. Department of Bioengineering, The University of Tokyo, Bunkyo, Tokyo, Japan |
| |
| Abstract: | 2‐Methacryloyloxyethyl phosphorylcholine (MPC) is a custom methacrylate with a zwitterionic phosphorylcholine moiety on the side chain. In the past 25 years, MPC has been used as a building block for a wide range of polymeric biomaterials because of its excellent resistance to nonspecific protein adsorption, cell adhesion, and blood coagulation. Recently, MPC polymers with specific features have been used in bioengineering and nanomedicine. This review focuses on three topics that highlight the latest findings on MPC polymers, that is, specific recognition of C‐reactive protein (CRP), cell‐membrane‐penetration abilities, and lubrication properties. These developments will extend the applications of this biomimetic material from bioinert polymers to biosensing, CRP inhibitors, prodrug carriers, subcellular bioimaging, cell manipulation, and joint replacement. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015 , 132, 41766. |
| |
| Keywords: | biomaterials biomimetic drug delivery systems molecular recognition surfaces and interfaces wear and lubrication |
|
|
