| 核酸适配体生物传感器在食品霉菌毒素检测中应用的研究进展 |
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| 引用本文： | 乔勤勤, 文芳, 郑楠, 薛秀恒, 程建波, 张昊, 李松励, 王加启. 核酸适配体生物传感器在食品霉菌毒素检测中应用的研究进展[J]. 食品工业科技, 2019, 40(16): 294-303. DOI: 10.13386/j.issn1002-0306.2019.16.050 |
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| 作者姓名： | 乔勤勤 文芳 郑楠 薛秀恒 程建波 张昊 李松励 王加启 |
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| 作者单位： | 1. 中国农业科学院北京畜牧兽医研究所, 动物营养学国家重点实验室, 农业农村部奶产品质量安全风险评估实验室(北京), 北京 100193;2. 安徽农业大学茶与食品科技学院, 安徽农产品加工工程实验室, 安徽合肥 230036;3. 安徽农业大学动物科技学院, 安徽合肥 230036 |
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| 基金项目： | 生鲜乳质量安全评价技术及生产规程研究与示范(201403071);国家自然科学基金青年科学基金项目(21305158);产业技术体系(CARS-36);中国农业科学院科技创新工程(ASTIP-IAS12) |
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| 摘 要： | 霉菌毒素是由霉菌产生的次级代谢物,是人类健康的主要威胁之一。食品中霉菌毒素的污染已经成为人们热切关注的主要食品安全问题之一,所以开发出用于简便、快速和灵敏检测食品中霉菌毒素的方法显得尤为重要。核酸适配体是在体外筛选,并能特异性识别目标物的单链寡核苷酸序列,因具有易合成、易标记、易修饰、灵敏度高、特异性高、分子量小等优势而广泛应用于蛋白质、霉菌毒素、农兽药等目标物检测的生物传感器。本文主要综述了食品中霉菌毒素的限量和危害,以及核酸适配体生物传感器筛选技术用于食品中霉菌毒素检测的研究进展。
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| 关 键 词： | 核酸适配体 生物传感器 霉菌毒素 限量 危害 食品中检测方法 |
| 收稿时间： | 2018-08-20 |
Research Progress of Nucleic Acid Aptamer Biosensors on Application of Mycotoxin Detection in Food |
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| QIAO Qin-qin, WEN Fang, ZHENG Nan, XUE Xiu-heng, CHENG Jian-bo, ZHANG Hao, LI Song-li, WANG Jia-qi. Research Progress of Nucleic Acid Aptamer Biosensors on Application of Mycotoxin Detection in Food[J]. Science and Technology of Food Industry, 2019, 40(16): 294-303. DOI: 10.13386/j.issn1002-0306.2019.16.050 |
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| Authors: | QIAO Qin-qin WEN Fang ZHENG Nan XUE Xiu-heng CHENG Jian-bo ZHANG Hao LI Song-li WANG Jia-qi |
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| Affiliation: | (Laboratory of Quality and Safety Risk Assessment for Dairy Products of Agriculture and Rural Affairs(Beijing),State Key Laboratory of Animal Nutrition,Institute of Animal Science,Chinese Academy of Agricultural Sciences,Beijing 100193 .China;Anhui Agricultural Products Processing Engineering Laboratory,Tea and Food Science and Technology College, Anhui Agricultural University, Hefei 230036, China;College of Animal Science and Technology,Anhui Agricultural University,Hefei 230036,China) |
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| Abstract: | Mycotoxin,a secondary metabolite produced by different molds,is one of the major threats to human health. The contamination of mycotoxin in food has become one of the main food safety problems,so it is very important to develop a simple,rapid and sensitive method for the detection of mycotoxins in foods. Nucleic acid aptamer,single chain oligonucleotide sequences,is widely used in the detection of proteins,mycotoxins and agricultural veterinary drugs to identify the targets in vitro,because of their advantages such as easy synthesis,easy labeling,easy modification,high sensitivity,high specificity and small molecular weight.The review summarized the limitations and hazards of mycotoxins in food and the research progress on nucleic acid aptamer screening assay for detection of mycotoxins in food. |
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| Keywords: | nucleic acid aptamer biosensors mycotoxin limitation hazards detection method in food |
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