| 俄色叶提取物对小鼠急性酒精性肝损伤的保护作用 |
| |
| 引用本文： | 曾俊, 杨瑞山, 蔡晓洋, 周海玉, 黄珍, 王盼, 李敏. 俄色叶提取物对小鼠急性酒精性肝损伤的保护作用[J]. 食品工业科技, 2017, (13): 311-314. DOI: 10.13386/j.issn1002-0306.2017.13.058 |
| |
| 作者姓名： | 曾俊 杨瑞山 蔡晓洋 周海玉 黄珍 王盼 李敏 |
| |
| 作者单位： | 1.成都中医药大学中药材标准化教育部重点实验室中药资源系统研究与开发利用国家重点实验室 |
| |
| 摘 要： | 目的:研究俄色叶提取物对小鼠酒精性肝损伤的保护作用。方法:采用体积分数为50%的乙醇一次性灌胃造成小鼠急性肝损伤,检测各组小鼠血清中谷丙转氨酶（ALT）、谷草转氨酶（AST）、甘油三酯（TG）、低密度脂蛋白（LDL-C）的水平,及肝组织匀浆中丙二醛（MDA）、超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-Px）水平的变化,同时HE染色观察肝脏组织学改变。结果:俄色叶提取物能不同程度地降低小鼠血清中ALT、AST、TG、LDL-C水平,减少肝匀浆MDA含量,升高肝匀浆SOD、GSH-Px的活性。病理切片显示各给药组小鼠肝组织损伤均有不同程度的减轻。结论:俄色叶提取物对小鼠急性酒精性肝损伤有一定的保护作用。
|
| 关 键 词： | 藏药 俄色叶 酒精性肝损伤 保护作用 |
| 收稿时间： | 2016-12-06 |
Hepatoprotective effects of Eseye extract on acute alcoholic liver damage in mice |
| |
| ZENG Jun, YANG Rui-shan, CAI Xiao-yang, ZHOU Hai-yu, HUANG Zhen, WANG Pan, LI Min. Hepatoprotective effects of Eseye extract on acute alcoholic liver damage in mice[J]. Science and Technology of Food Industry, 2017, (13): 311-314. DOI: 10.13386/j.issn1002-0306.2017.13.058 |
| |
| Authors: | ZENG Jun YANG Rui-shan CAI Xiao-yang ZHOU Hai-yu HUANG Zhen WANG Pan LI Min |
| |
| Affiliation: | 1.Chengdu University of Traditional Chinese Medicine, The Ministry of Education Key Laboratory for Standardization of Chinese Medicines, State Key Laboratory Breeding Base of Systematic Research Development and Utilization of Chinese Medicines Resources Co-founded by Sichuan Province and Ministry of Science and Technology |
| |
| Abstract: | Objective: To investigate the hepatoprotective effects of Eseye extracts against alcohol-induced acute liver injury in mice.Method: The acute liver injury animal model was established in mice by alcohol gavage ( 50%) .The serum levels of ALT, AST, LDL-C and TG were determined. MDA, SOD and GSH-Px were detected in the liver homogenate, as well as the histopathological changes of the liver were observed by HE staining.Result: Eseye extract decreased the levels of ALT, AST, TG and LDL-C in serum.Meanwhile, the MDA content in liver homogenate was reduced whereas the activity of SOD and GSH-Px were increased by Eseye extract.According to the liver histopathological observation, all of treatment groups showed alleviation in mice liver injury to varying degrees.Conclusion: Eseye extract has protective effects on acute liver injury induced by alcohol in mice. |
| |
| Keywords: | Tibetan medicine Eseye alcoholic liver injury preventive effect |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《食品工业科技》浏览原始摘要信息 |
|
点击此处可从《食品工业科技》下载全文 |
|
