| EGCG对局灶性脑缺血损伤的作用研究 |
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| 引用本文： | 蔡飞,李彩蓉,吴基良,陈金和. EGCG对局灶性脑缺血损伤的作用研究[J]. 食品科学, 2006, 27(9): 247-249 |
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| 作者姓名： | 蔡飞 李彩蓉 吴基良 陈金和 |
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| 作者单位： | 咸宁学院药学院药理教研室； 咸宁学院病理教研室； 武汉大学医学院药理学系；中科技大学同济医学院药理学系； |
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| 摘 要： | 目的:探讨表没食子儿茶素没食子酸酯(EGCG)对大鼠局灶性脑缺血损伤的作用及其可能机制。方法:采用线拴法建立大鼠大脑中动脉栓塞(MCAO)模型。大鼠随机分为假手术组、缺血组、EGCG小剂量组(10mg/kg)、EGCG大剂量组(20mg/kg)、尼莫地平组。缺血前30min舌下静脉给药,持续性缺血6h后处死动物。测定脑梗塞体积、脑组织钙和兴奋性氨基酸含量。结果:与模型组相比EGCG治疗组能减小脑梗塞体积,显著降低脑组织钙及兴奋性氨基酸含量。结论:EGCG对大鼠局灶性脑缺血具有防治作用,其作用机制可能与防止细胞内钙超载、减少兴奋性氨基酸的毒性有关。
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| 关 键 词： | EGCG(表没食子儿茶素没食子酸酯) 局灶性脑缺血 兴奋性氨基酸 |
| 文章编号： | 1002-6630（2006）09-0247-03 |
| 收稿时间： | 2005-10-24 |
| 修稿时间： | 2005-10-24 |
Study on Effects of EGCG on Experimental Focal Brain Ischemia Injury in Rats |
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| CAI Fei,LI Cai-rong,WU Ji-liang,CHEN Jin-he. Study on Effects of EGCG on Experimental Focal Brain Ischemia Injury in Rats[J]. Food Science, 2006, 27(9): 247-249 |
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| Authors: | CAI Fei LI Cai-rong WU Ji-liang CHEN Jin-he |
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| Affiliation: | 1.Division of Pharmacology, School of Pharmacy, Xianning College, Xianning 437100, China; 2.Division of Pathology, Xianning College, Xianning 437100, China;3.Department of Pharmacology, College of Medical, Wuhan University, Wuhan 430071, China;4.Department of Pharymacology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China |
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| Abstract: | Objective: To study the protective effects and mechanism of EGCG (Epigallocatechin-3-gallate) on focal brain ischemia injury in rats. Methods: The ischemia model was created by right middle cerebral artery occlusion(MCAO). Rats were randomly divided into five groups. The EGCG groups were treated by EGCG 30min before MCAO. The sizes of cerebral infarction were measured after 6h of MCAO. The content of Ca2 and excitatory amino acids in brain tissue were also determined. Results: The sizes of cerebral infarction of EGCG groups are less than that of the ischemia group. The contents of Ca2 and excitatory amino acids of EGCG groups decrease more significantly than those of the ischemia group. Conclusion: EGCG may have the protective effects on focal brain ischemia injury in rats through reducing the content of Ca2 and excitatory amino acids in brain tissue. |
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| Keywords: | EGCG(Epigallocatechin-3-gallate) MCAO(middle cerebral artery occlusion) excitatory amino acids |
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