Adhesion between polymer surface modified by graft polymerization and tissue during surgery using an ultrasonically activated scalpel device |
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| Authors: | Kwangwoo Nam Takuya Iwata Tsuyoshi Kimura Hiroki Ikake Shigeru Shimizu Toru Masuzawa Akio Kishida |
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| Affiliation: | 1. Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Chiyoda‐ku, Tokyo, Japan;2. Department of Materials and Applied Chemistry, College of Science and Technology, Nihon University, Chiyoda‐ku, Tokyo, Japan;3. Faculty of Engineering, Ibaraki University, Hitachi‐shi, Ibaraki, Japan |
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| Abstract: | In the field of surgery, achieving adhesion between a polymer implant and tissue poses a challenge considering that suturing is not appropriate for the stability of such implants. An ultrasonically activated scalpel that generates heat by mechanical vibration and promotes adhesion between a polymer implant and native tissue by pressing the two materials together has very good potential for application in the field. To determine the type of polymer that is suitable for the purpose, we investigated polyethylene (PE) and polystyrene (PS) films, the surfaces of which were activated by corona discharge. Graft polymerization was then performed on the corona‐treated surfaces to vary their properties. The corona‐treated PE and PS films grafted with poly(acrylic acid), poly(methacrylic acid), poly(vinyl benzylacrylic acid), and poly(hydroxylethyl acrylate), respectively, adhered to the tissue when the ultrasonically activated scalpel was applied. The heat generated by the mechanical vibration and the applied pressure enabled the carboxyl or hydroxyl groups to bond with the proteins in the extracellular matrix. We therefore concluded that it was possible to integrate this technique in the development of new types of polymer devices that could be stably implanted in a living body. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014 , 131, 40885. |
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| Keywords: | biomedical applications films surfaces and interfaces |
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