Thermally and magnetically dual‐responsive mesoporous silica nanospheres: preparation,characterization, and properties for the controlled release of sophoridine |
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| Authors: | Liling Dong Hailong Peng Shenqi Wang Zhong Zhang Jinhua Li Fanrong Ai Qiang Zhao Mei Luo Hua Xiong Lingxin Chen |
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| Affiliation: | 1. State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, China;2. Department of Chemical Engineering, Nanchang University, Nanchang, China;3. Key Laboratory of Coastal Zone Environmental Processes and Ecological Remediation, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai, China;4. Department of Mechanical Engineering, Nanchang University, Nanchang, China |
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| Abstract: | Novel thermally and magnetically dual‐responsive mesoporous silica nanoparticles [magnetic mesoporous silica nanospheres (M‐MSNs)–poly(N‐isopropyl acrylamide) (PNIPAAm)] were developed with magnetic iron oxide (Fe3O4) nanoparticles as the core, mesoporous silica nanoparticles as the sandwiched layer, and thermally responsive polymers (PNIPAAm) as the outer shell. M‐MSN–PNIPAAm was initially used to control the release of sophoridine. The characteristics of M‐MSN–PNIPAAm were investigated by transmission electron microscopy, Fourier transform infrared spectroscopy, X‐ray diffraction, thermogravimetry, N2 adsorption–desorption isotherms, and vibrating specimen magnetometry analyses. The results indicate that the Fe3O4 nanoparticles were incorporated into the M‐MSNs, and PNIPAAm was grafted onto the surface of the M‐MSNs via precipitation polymerization. The obtained M‐MSN–PNIPAAm possessed superparamagnetic characteristics with a high surface area (292.44 m2/g), large pore volume (0.246 mL/g), and large mesoporous pore size (2.18 nm). Sophoridine was used as a drug model to investigate the loading and release properties at different temperatures. The results demonstrate that the PNIPAAm layers on the surface of M‐MSN–PNIPAAm effectively regulated the uptake and release of sophoridine. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014 , 131, 40477. |
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| Keywords: | biocompatibility biomedical applications functionalization of polymers drug‐delivery systems stimuli‐sensitive polymers |
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