Advancing Small‐Molecule‐Based Chemical Biology with Next‐Generation Sequencing Technologies |
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| Authors: | Chandran Anandhakumar Seiichiro Kizaki Dr. Toshikazu Bando Dr. Ganesh N. Pandian Prof. Dr. Hiroshi Sugiyama |
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| Affiliation: | 1. Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo‐ku, Kyoto 606‐8502 (Japan);2. Institute for Integrated Cell‐Material Sciences (iCeMS), Kyoto University, Yoshida‐ushinomiyacho, Sakyo‐ku, Kyoto 606‐8501 (Japan) |
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| Abstract: | Next‐generation‐sequencing (NGS) technologies enable us to obtain extensive information by deciphering millions of individual DNA sequencing reactions simultaneously. The new DNA‐sequencing strategies exceed their precursors in output by many orders of magnitude, resulting in a quantitative increase in valuable sequence information that could be harnessed for qualitative analysis. Sequencing on this scale has facilitated significant advances in diverse disciplines, ranging from the discovery, design, and evaluation of many small molecules and relevant biological mechanisms to maturation of personalized therapies. NGS technologies that have recently become affordable allow us to gain in‐depth insight into small‐molecule‐triggered biological phenomena and empower researchers to develop advanced versions of small molecules. In this review we focus on the overlooked implications of NGS technologies in chemical biology, with a special emphasis on small‐molecule development and screening. |
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| Keywords: | aptamers chemical biology genomics next‐generation sequencing small molecules |
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