|
|||||
|
|
Tetrazine‐Responsive Self‐immolative Linkers |
|
| Authors: | Kevin Neumann Sarthak Jain Alessia Gambardella Dr. Sarah E. Walker Dr. Elsa Valero Dr. Annamaria Lilienkampf Prof. Mark Bradley |
| Affiliation: | EaStCHEM School of Chemistry, University of Edinburgh, Edinburgh, UK |
| Abstract: | Molecules that undergo activation or modulation following the addition of benign external small‐molecule chemical stimuli have numerous applications. Here, we report the highly efficient “decaging” of a variety of moieties by activation of a “self‐immolative” linker, by application of water‐soluble and stable tetrazine, including the controlled delivery of doxorubicin in a cellular context. |
| Keywords: | Diels– Alder reaction doxorubicin nanoparticles prodrugs tetrazine |