Screw sockets: survivorship analysis after eight years

The enhancing effect of o-vanillin (2-hydroxy-3-methoxybenz-aldehyde) on mutations induced by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) was characterized with mutational specificity. The mutational spectrum of MNNG-induced mutations in the presence of o-vanillin was compared with that in the absence of o-vanillin by means of a series of mutant lacZ genes in E. coli that can detect each of the six types of base substitutions and five kinds of frameshift events. In the absence of o-vanillin, the mutational spectrum induced by MNNG consisted mainly of G.C-->A.T transitions and, to a lesser extent, -1(G.C) frameshift mutations. By adding o-vanillin at 75 micrograms/plate, a marked enhancement was observed in two transitions, G.C-->A.T and A.T-->G.C, and in two frameshift mutations, +1(G.C) and -1(G.C). Only a small change was observed in the -2(C.G-G.C) fraction. Regarding the MNNG-induced frameshifts at the A.T base pair, the +1(A.T) frameshift was much more enhanced by o-vanillin than the -1(A.T) frameshift.     

Parathyroidectomy after renal transplantation: a retrospective analysis of long-term outcome

BACKGROUND: Advanced hyperparathyroidism refractory to active vitamin D continues to be a problem and frequently forces the nephrologist to resort to parathyroidectomy. One particular aspect is persisting advanced hyperparathyroidism after renal transplantation. Published information on this point is fragmentary. DESIGN: Retrospective analysis. PATIENTS: Between 1983 and 1995 a total of 456 patients with renal secondary hyperparathyroidism were subjected to parathyroidectomy (PTX) of whom 103 were transplanted or had at least a history of renal transplantation. The present analysis concerns 37 patients who had a functional renal graft at the time of PTX and were followed for up to 13 years. PTX was performed after an average of 36.7 months after renal transplantation. OUTCOME: Thirteen patients experienced rejection and became dialysis-dependent. Twenty-four patients had stable function of the renal graft. Seven patients died during follow-up. Hypoparathyroidism post-PTX developed in 4/37 patients, but could be overcome by replantation of cryoconserved parathyroid tissue. FREQUENCY ESTIMATE: A total of 2632 renal transplants were performed in the catchment area. As a minimum estimate 3.91% of patients with a functional graft required PTX. RECOMMENDATION: Parathyroidectomy should be considered early in cases with advanced secondary renal hyperparathyroidism, since renal transplantation does not necessarily guarantee reversibility of parathyroid overactivity.     

Recurrent hyperthyroidism after thyroidectomy

For 53 patients with toxic recurrent goiter (TRG), the interval between thyroidectomy and recurrent hyperthyroidism range from six months to 50 years (average, 12.4 +/- 11.9 years). Recurrent hyperthyroidism may occur in older patients for whom cardiac decompensation may be the initial manifestation. Reports on surgically treated hyperthyroid patients may underestimate the incidence of TRG unless follow-up is extended for many years.     

Treatment of hyperthyroidism with radioactive iodine

Treatment of hyperthyroidism with RAI has been performed for more than a half century with efficacy and safety. For its optimal use, the physician must employ appropriate patient selection criteria and clinical judgment concerning pretreatment patient preparation. The dose of the 131I needed remains an area of uncertainty and debate; thus far, it has not been possible to resolve the trade-off between efficient definitive cure of hyperthyroidism and the high incidence of post-therapy hypothyroidism. Early side effects are uncommon and readily manageable. Other than the need for long-term monitoring and, in most cases, lifelong L-T4 treatment, late adverse consequences of this treatment remain only conjectural. The available follow-up studies support the current majority opinion of North American thyroid specialists that RAI treatment is an excellent choice for most hyperthyroid patients.     

落实科学发展观 追求钢铁强国梦

30年前,党的十一届三中全会,做出把党和国家工作中心转移到经济建设上来、实行改革开放的历史性决策,吹响了走自己的路、建设中国特色社会主义的时代号角,中国人民从此踏上了改革开放的伟大历史征程。30年来,以邓小平同志为核心的党的第二代中央领导集体、以江泽民同志为核心的党的第三代中央领导集体和以胡锦涛同志为总书记的党中央,团结带领全党全国各族人民,     

Symptoms of temporomandibular joint osteoarthrosis and internal derangement 30 years after non-surgical treatment

To evaluate the long-term condition of temporomandibular joints (TMJs) affected by osteoarthrosis and internal derangement, 99 patients treated non-surgically between 1958 and 1962 were recalled for follow-up. The patients, 16 men and 83 women (mean age 58.2 years) with either reducing or permanent disk displacement, were submitted to a structured interview concerning previous treatment, masticatory function, and the presence of symptoms of osteoarthrosis and internal derangement of the masticatory system, and of complaints of the musculoskeletal system in general. A control group, consisting of eight men and 27 women (mean age 58.9 years) without complaints of the masticatory system, matching the patient group for sex, age and state of dentition, was included in the study to avoid simply documenting age-related joint conditions. Satisfaction with the treatment outcome was high. Chewing ability of the the patients did not differ from that of the controls, although patients more often expected pain and difficulty with opening the mouth wide. The main TMJ symptoms of the patients had decreased significantly; patients reported joint noises more often than controls. It is concluded that, despite some persisting symptoms, the non-surgical treatment approach of TMJ osteoarthrosis and internal derangement provides long-lasting satisfactory subjective results and is well-accepted by the patients.     

Labyrinthine fistulae: a retrospective analysis

We have designed a dihedral osteotomy of the greater trochanter which is V-shaped with the apex infero-medially. A single screw is used for fixation. The osteotomy was used in 24 hips (23 patients), as part of a transtrochanteric approach for acetabular reconstruction, carried out for dysplasia or in complicated acetabular fractures. There were no cases of nonunion or painful bursitis at an average follow up of 20 months. The method provides a stable reduction and bony union because of the self-compressive effect of the abductor muscles.     

Extraversion and vigilance performance: 30 years of inconsistencies.

Deteriorating efficiency in detecting critical events is a pervasive phenomenon. It has been asserted that the personality dimension of extraversion–introversion (E-I) could serve as a selection device: Introverts would be superior in sustained attention. A meta-analysis revealed better performance of introverts, but the effect size was small because of a high incidence of inconsistencies. In a subset of the studies, the effect size was much larger: Introverts were superior in overall level of correct detections but not in maintaining efficiency over time. Inconsistent findings may partly have been caused by inappropriate use of univariate ANOVA in repeated measures designs. The validity of some "classic" findings in the vigilance literature was questioned. The relationship of E-I to electrodermal speed of habituation was discussed. Finally, here also a trend was noted to move to new problems before solving old ones. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Treatment of perforated appendicitis: an analysis of 362 patients treated during 8 years

BACKGROUND AND METHOD: In a retrospective study 2,351 records from patients who underwent surgery for acute appendicitis during 1986-1993 were analysed. During this period, there were 362 patients with perforated appendicitis. The aim of this study was to analyse the complication rate, the period of antibiotic treatment and whether the complication rate decreased when intravenous treatment was followed by oral antibiotic treatment. RESULTS: The complication frequency was 18% which was significantly higher than that for non-perforated appendicitis of 10%. The complication rate was 15% in the group receiving additional oral antibiotics compared to 19% in the group receiving only intravenous antibiotics. This difference is not significant. CONCLUSION: Perforated appendicitis is however still associated with increased mortality and morbidity.     

Postoperative infection after transsternal thymectomy for myasthenia gravis: a retrospective analysis of 125 cases

The goat milk lactoperoxidase was purified using CM sephadex C-50 and sephadex G 100. The purity of protein was confirmed by SDS-PAGE. The purified protein was found to have antibacterial action against most of the disease causing bacteria.     

30 years later: children attending a counseling service up to 3 years of age

From 1953 through 1955 a total of 2364 individuals between o and 18 years were discharged from the Stockholm Child Guidance Clinics. Among these patients 125 (68 boys, 57 girls) were under the age of 3 years. A follow-up study was conducted 30 years later on this sample using records from psychiatric clinics and data from official registers of problematic behaviours. The majority of the infants when seen at the Child Guidance Clinics were judged to be mentally healthy or to have shown mild environmental reactions. However sixty per cent of these patients were identified in at least one of the registers during the follow-up period. Thus the initial evaluation was not prognostic of the future development. Boys developed mainly social maladjustment, whereas girls more often applied for psychiatric care during the follow-up. Significant prognostic factors in the 1950s were gender and parental psychiatric diagnosis.     

Manifestation of primary hyperthyroidism after pituitary adenomectomy: a case report

We report a 47-year-old Japanese man who presented with visual disturbance due to a pituitary tumor with suprasellar extension. The patient had mild secondary hypothyroidism preoperatively, and was started on administration of levothyroxine sodium immediately before transsphenoidal surgery. After the operation, levothyroxine sodium was continued for several months. Pathological examination of the surgical specimen, together with endocrinological investigation revealed that the suprasellar tumor was a FSH-producing pituitary adenoma. Since 3 months after the operation, he has developed muscle weakness and finger tremor. He was found to be thyrotoxicosis, and levothyroxine sodium was discontinued. Seven weeks after levothyroxine sodium was discontinued, thyrotoxicosis continued, with a positive thyrotropin binding inhibitory immunoglobulin (TBII) and a high diffuse 123I-uptake by the thyroid. He was started on thiamazole 30 mg/day. Although his thyroid dysfunction improved within 2 months, hyperthyroidism worsened repeatedly on attempts to discontinue thiamazole, and he required continuous treatment at 2.5 mg/day. Patients with occult autoimmune thyroiditis rarely progress to thyrotoxicosis after operations on other endocrine organs such as the adrenal or parathyroid gland. In patients with pituitary adenoma, thyroid function and thyroid-associated autoantibodies should be investigated pre- and post-operatively.     

改革开放—铸就钢铁强国的必由之路——纪念中国钢铁工业改革开放30周年

1978年中国共产党十一届三中全会拉开了我国改革开放的大幕,至今我国已经走过了不断探索、不断进步的30年改革开放历程,取得了举世瞩目的伟大成就。钢铁工业作为我国最重要的基础原材料产业之一,与国家改革开放、经济发展与社会进步的步伐息息相连。30年来,钢铁行业在党中央、国务院的正确领导下,在改革开放方针的指引下,在各地方和相关行业的大力支持下,经过几代钢铁人的不懈努力,已把自身打造成为一个管理体制和运行机制基本适应社会主义市场经济环境、产品数量、品种和质量能够基本满足国民经济和有关行业发展的需要、具有一定国际竞争力和技术开发创新能力、在世界钢铁业有举足轻重地位的产业。     

Timing of thromboembolic events after electrical cardioversion of atrial fibrillation or flutter: a retrospective analysis

Pooled data from 32 studies were reviewed to assess the timing of thrombolic complications after cardioversion of atrial fibrillation or flutter. We found that 98% of embolic episodes occurred within 10 days of cardioversion.     

Risks and benefits of diagnostic angiography after aneurysm surgery: a retrospective analysis of 597 studies

INTRODUCTION: Cerebral angiography performed after aneurysm surgery can identify causes of morbidity and mortality that may be corrected. The risks and benefits of angiography that is performed after aneurysm surgery, however, have not been clearly defined. We therefore reviewed our experience with postoperative angiography to determine its dangers and benefits. METHODS: During 10 years, 543 consecutive patients received treatment for cerebral aneurysms. A retrospective analysis of 597 diagnostic angiograms obtained after aneurysm surgery for 494 of these patients was performed. RESULTS: Catheter-induced vessel spasm and dissection, occurring most frequently in the internal carotid artery, were observed in seven (1.2%) and six (1%) studies, respectively. No angiography-associated strokes were identified. No association between age, smoking, hypertension, blood pressure, atherosclerosis, or severe vasospasm and angiographic complications was observed. Aneurysm remnants were identified in 36 (5.7%) of the 637 aneurysms that were surgically treated. Atherosclerosis (P < 0.01) or multiple clip applications (P < 0.01) were significantly associated with aneurysm remnants. Angiographic vessel occlusion was observed in 28 (5.7%) patients and resulted in stroke in 14 of these patients. Vessel occlusion was significantly associated with increasing aneurysm size (P < 0.001), atherosclerosis (P < 0.001), temporary clips (P < 0.001), multiple clips (P=0.03), multiple clip applications (P=0.001), and a new postoperative neurological deficit (P=0.002). Severe vasospasm and newly identified aneurysms were observed in 51 and 16 patients, respectively. CONCLUSION: Angiography after aneurysm surgery is safe and can be routinely performed. Angiography after aneurysm surgery should be particularly considered for patients with large aneurysms or cerebrovascular atherosclerosis and for those who develop new postoperative neurological deficits.     

Primitive cerebral neuroectodermal tumors excluding medulloblastomas: a retrospective study of 30 cases

We present a retrospective study of 30 cases of primitive cerebral neuroectodermal tumors (PNET), excluding medulloblastomas, referred to us postoperatively for additional therapy to evaluate prognostic factors and treatment efficiency. The histologic types were: pinealoblastomas (n = 7); ependymoblastomas (n = 2); medulloepitheliomas (n = 4), and other PNET (n = 17). The tumor was located in the supratentorial area in 24 patients and in the posterior fossa in 6 patients. Among the supratentorial tumors, 8 were metastatic. Maximal surgical resection was performed. Sixteen of 30 patients had no measurable disease after surgery and were considered as standard-risk (SR) cases, and 14 with a local residue or metastasis as high-risk (HR) cases. The objective of postsurgical treatment was to avoid radiotherapy in children below 4 years of age. It consisted of radiotherapy alone in 6 patients, chemotherapy alone in 17, and radiotherapy with chemotherapy in 7. Furthermore, high-dose chemotherapy (busulfan, thiotepa) and autologous bone marrow transplantation, performed in 6 patients, yielded a response rate of 3/6. Event-free survival (EFS) of SR patients was 37% at 3 years (95% confidence interval (CI) 14-60%) and overall survival 44% (95% CI 26-62%). Only 1 of the HR patients achieved a complete remission and all of them died early. The critical prognostic factors appear to be the completeness of initial surgical resection and absence of metastasis. These tumors have a poor prognosis. Novel strategies (high-dose chemotherapy) are needed to improve their outcome because the children concerned are very young and the effects of radiotherapy are particularly deleterious when tumors are situated in the supratentorial area.