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Abraham S. Moses Olena R. Taratula Hyelim Lee Fangzhou Luo Tanner Grenz Tetiana Korzun Anna St Lorenz Fahad Y. Sabei Shay Bracha Adam W. G. Alani Ov D. Slayden Oleh Taratula 《Small (Weinheim an der Bergstrasse, Germany)》2020,16(18)
Endometriosis is a painful disorder where endometrium‐like tissue forms lesions outside of the uterine cavity. Intraoperative identification and removal of these lesions are difficult. This study presents a nanoplatform that concurrently delineates and ablates endometriosis tissues using real‐time near‐infrared (NIR) fluorescence and photothermal therapy (PTT). The nanoplatform consists of a dye, silicon naphthalocyanine (SiNc), capable of both NIR fluorescence imaging and PTT, and a polymeric nanoparticle as a SiNc carrier to endometriosis tissue following systemic administration. To achieve high contrast during fluorescence imaging of endometriotic lesions, nanoparticles are constructed to be non‐fluorescent prior to internalization by endometriosis cells. In vitro studies confirm that these nanoparticles activate the fluorescence signal following internalization in macaque endometrial stromal cells and ablate them by increasing cellular temperature to 53 °C upon interaction with NIR light. To demonstrate in vivo efficiency of the nanoparticles, biopsies of endometrium and endometriosis from rhesus macaques are transplanted into immunodeficient mice. Imaging with the intraoperative Fluobeam 800 system reveals that 24 h following intravenous injection, nanoparticles efficiently accumulate in, and demarcate, endometriotic grafts with fluorescence. Finally, the nanoparticles increase the temperature of endometriotic grafts up to 47 °C upon exposure to NIR light, completely eradicating them after a single treatment. 相似文献
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Weixuan Zeng Tao Zhou Weimin Ning Cheng Zhong Jiawei He Shaolong Gong Guohua Xie Chuluo Yang 《Advanced materials (Deerfield Beach, Fla.)》2019,31(33)
Developing high‐efficiency solution‐processable thermally activated delayed‐fluorescence (TADF) emitters, especially in longer wavelength regions, is a formidable challenge. Three red TADF emitters, namely NAI_R1, NAI_R2, and NAI_R3, are developed by phenyl encapsulation and tert‐butyl substitution on a prototypical 1,8‐naphthalimide‐acridine hybrid. This design strategy not only grants these molecules high solubility, excellent thermal stability, and good film‐forming ability, but also pulls down their charge‐transfer (CT) energy levels excited states. Furthermore, dispersing these emitters into two different host materials of mCP and mCPCN finely tailors their CT‐state energy levels. More importantly, a synergistic combination of molecular engineering and host selection can effectively manipulate the competition between the radiative and nonradiative decay rates of the CT singlet states of these emitters and the reverse intersystem crossing from their triplet to singlet states. Consequently, the optimal combination of NAI_R3 emitter and mCP host successfully results in a state‐of‐the‐art external quantum efficiency (EQE) of 22.5% for solution‐processed red TADF organic light‐emitting diodes (OLEDs) with an emission peak above 620 nm. This finding demonstrates that a synergistic strategy of molecular engineering and host selection with TADF emitters could provide a new pathway for developing efficient solution‐processable TADF systems. 相似文献